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1ijv

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[[Image:1ijv.jpg|left|200px]]<br /><applet load="1ijv" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1ijv, resolution 1.20&Aring;" />
 
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'''HUMAN BETA-DEFENSIN-1'''<br />
 
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==Overview==
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==HUMAN BETA-DEFENSIN-1==
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Defensins are a class of small cationic peptides found in higher organisms, that serve as both antimicrobial and cell signaling molecules. The exact, mechanism of the antimicrobial activity of defensins is not known, but two, models have been postulated, one involving pore formation and the other, involving nonspecific electrostatic interaction with the bacterial, membrane. Here we report the high resolution structures of human, beta-defensin-1 (hBD1) in two crystallographic space groups. The structure, of a single molecule is very similar to that of human beta-defensin-2, (hBD2), confirming the presence of an N-terminal alpha-helix. However, while the packing of hBD1 is conserved across both space groups, there is, no evidence for any larger quaternary structure similar to octameric hBD2., Furthermore, the topology of hBD1 dimers that are formed between monomers, in the asymmetric unit is distinct from both hBD2 and other mammalian, alpha-defensins. The structures of hBD1 and hBD2 provide a first step, toward understanding the structural basis of antimicrobial and chemotactic, properties of human beta-defensins.
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<StructureSection load='1ijv' size='340' side='right'caption='[[1ijv]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1ijv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IJV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IJV FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ijv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ijv OCA], [https://pdbe.org/1ijv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ijv RCSB], [https://www.ebi.ac.uk/pdbsum/1ijv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ijv ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DEFB1_HUMAN DEFB1_HUMAN] Has bactericidal activity (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ij/1ijv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ijv ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1IJV is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=SO4:'>SO4</scene>, <scene name='pdbligand=BR:'>BR</scene> and <scene name='pdbligand=K:'>K</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IJV OCA].
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*[[Defensin 3D structures|Defensin 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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The structure of human beta-defensin-1: new insights into structural properties of beta-defensins., Hoover DM, Chertov O, Lubkowski J, J Biol Chem. 2001 Oct 19;276(42):39021-6. Epub 2001 Aug 2. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11486002 11486002]
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[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Hoover, D.M.]]
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[[Category: Hoover DM]]
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[[Category: Lubkowski, J.]]
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[[Category: Lubkowski J]]
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[[Category: BR]]
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[[Category: K]]
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[[Category: SO4]]
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[[Category: beta-defensin]]
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[[Category: defensin]]
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[[Category: human beta-defensin-1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:01:49 2008''
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Current revision

HUMAN BETA-DEFENSIN-1

PDB ID 1ijv

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