This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1ik0

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /> <applet load="1ik0" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ik0" /> '''Solution Structure of Human IL-13'''<br /> ...)
Current revision (07:47, 3 April 2024) (edit) (undo)
 
(18 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1ik0.gif|left|200px]]<br />
 
-
<applet load="1ik0" size="450" color="white" frame="true" align="right" spinBox="true"
 
-
caption="1ik0" />
 
-
'''Solution Structure of Human IL-13'''<br />
 
-
==Overview==
+
==Solution Structure of Human IL-13==
-
Interleukin-13 has been implicated as a key factor in asthma, allergy, atopy and inflammatory response, establishing the protein as a valuable, therapeutic target. The high-resolution solution structure of human IL-13, has been determined by multidimensional NMR. The resulting structure is, consistent with previous short-chain left-handed four-helix bundles, where, a significant similarity in the folding topology between IL-13 and IL-4, was observed. IL-13 shares a significant overlap in biological function, with IL-4, a result of the common alpha chain component (IL-4Ralpha) in, their respective receptors. Based on the available structural and, mutational data, an IL-13/IL-4Ralpha model and a sequential mechanism for, forming the signaling heterodimer is proposed for IL-13.
+
<StructureSection load='1ik0' size='340' side='right'caption='[[1ik0]]' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1ik0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IK0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IK0 FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ik0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ik0 OCA], [https://pdbe.org/1ik0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ik0 RCSB], [https://www.ebi.ac.uk/pdbsum/1ik0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ik0 ProSAT]</span></td></tr>
 +
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/IL13_HUMAN IL13_HUMAN] Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH) [MIM:[https://omim.org/entry/607154 607154]. Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure.
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/IL13_HUMAN IL13_HUMAN] Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ik/1ik0_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ik0 ConSurf].
 +
<div style="clear:both"></div>
-
==Disease==
+
==See Also==
-
Known diseases associated with this structure: Allergic rhinitis, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147683 147683]], Asthma, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147683 147683]]
+
*[[Interleukin 3D structures|Interleukin 3D structures]]
-
 
+
__TOC__
-
==About this Structure==
+
</StructureSection>
-
1IK0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1IK0 OCA].
+
-
 
+
-
==Reference==
+
-
Solution structure of human IL-13 and implication for receptor binding., Moy FJ, Diblasio E, Wilhelm J, Powers R, J Mol Biol. 2001 Jun 29;310(1):219-30. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11419948 11419948]
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Diblasio, E.]]
+
[[Category: Diblasio E]]
-
[[Category: Moy, F.J.]]
+
[[Category: Moy FJ]]
-
[[Category: Powers, R.]]
+
[[Category: Powers R]]
-
[[Category: Wilhelm, J.]]
+
[[Category: Wilhelm J]]
-
[[Category: left-handed four-helix bundle]]
+
-
 
+
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 17:30:46 2007''
+

Current revision

Solution Structure of Human IL-13

PDB ID 1ik0

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ik0"
Personal tools