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1il8

From Proteopedia

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{{Seed}}
 
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[[Image:1il8.png|left|200px]]
 
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<!--
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==THREE-DIMENSIONAL STRUCTURE OF INTERLEUKIN 8 IN SOLUTION==
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The line below this paragraph, containing "STRUCTURE_1il8", creates the "Structure Box" on the page.
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<StructureSection load='1il8' size='340' side='right'caption='[[1il8]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1il8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IL8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IL8 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1il8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1il8 OCA], [https://pdbe.org/1il8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1il8 RCSB], [https://www.ebi.ac.uk/pdbsum/1il8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1il8 ProSAT]</span></td></tr>
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{{STRUCTURE_1il8| PDB=1il8 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IL8_HUMAN IL8_HUMAN] IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.<ref>PMID:2145175</ref> <ref>PMID:2212672</ref> <ref>PMID:11978786</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/il/1il8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1il8 ConSurf].
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<div style="clear:both"></div>
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===THREE-DIMENSIONAL STRUCTURE OF INTERLEUKIN 8 IN SOLUTION===
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==See Also==
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*[[Interleukin 3D structures|Interleukin 3D structures]]
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== References ==
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<!--
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_2184886}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 2184886 is the PubMed ID number.
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</StructureSection>
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-->
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{{ABSTRACT_PUBMED_2184886}}
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==About this Structure==
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1IL8 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IL8 OCA].
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==Reference==
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<ref group="xtra">PMID:2184886</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Clore, G M.]]
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[[Category: Large Structures]]
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[[Category: Gronenborn, A M.]]
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[[Category: Clore GM]]
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[[Category: Cytokine]]
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[[Category: Gronenborn AM]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 13:41:26 2009''
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Current revision

THREE-DIMENSIONAL STRUCTURE OF INTERLEUKIN 8 IN SOLUTION

PDB ID 1il8

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