1irf

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{{Seed}}
 
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[[Image:1irf.png|left|200px]]
 
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==INTERFERON REGULATORY FACTOR-2 DNA BINDING DOMAIN, NMR, MINIMIZED AVERAGE STRUCTURE==
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The line below this paragraph, containing "STRUCTURE_1irf", creates the "Structure Box" on the page.
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<StructureSection load='1irf' size='340' side='right'caption='[[1irf]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1irf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IRF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IRF FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1irf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1irf OCA], [https://pdbe.org/1irf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1irf RCSB], [https://www.ebi.ac.uk/pdbsum/1irf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1irf ProSAT]</span></td></tr>
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{{STRUCTURE_1irf| PDB=1irf | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IRF2_MOUSE IRF2_MOUSE] Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ir/1irf_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1irf ConSurf].
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<div style="clear:both"></div>
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===INTERFERON REGULATORY FACTOR-2 DNA BINDING DOMAIN, NMR, MINIMIZED AVERAGE STRUCTURE===
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==See Also==
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*[[Interferon regulatory factor|Interferon regulatory factor]]
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__TOC__
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<!--
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_9562558}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 9562558 is the PubMed ID number.
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-->
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{{ABSTRACT_PUBMED_9562558}}
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==About this Structure==
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1IRF is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IRF OCA].
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==Reference==
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<ref group="xtra">PMID:9562558</ref><references group="xtra"/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Furui, J.]]
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[[Category: Furui J]]
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[[Category: Harada, H.]]
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[[Category: Harada H]]
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[[Category: Kyogoku, Y.]]
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[[Category: Kyogoku Y]]
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[[Category: Shirakawa, M.]]
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[[Category: Shirakawa M]]
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[[Category: Swindells, M B.]]
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[[Category: Swindells MB]]
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[[Category: Taniguchi, T.]]
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[[Category: Taniguchi T]]
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[[Category: Uegaki, K.]]
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[[Category: Uegaki K]]
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[[Category: Yamazaki, T.]]
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[[Category: Yamazaki T]]
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[[Category: Transcription regulation]]
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[[Category: Winged helix-turn-helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 07:46:33 2009''
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Current revision

INTERFERON REGULATORY FACTOR-2 DNA BINDING DOMAIN, NMR, MINIMIZED AVERAGE STRUCTURE

PDB ID 1irf

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