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1itl

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{{Seed}}
 
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[[Image:1itl.png|left|200px]]
 
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==HUMAN INTERLEUKIN 4: THE SOLUTION STRUCTURE OF A FOUR-HELIX-BUNDLE PROTEIN==
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The line below this paragraph, containing "STRUCTURE_1itl", creates the "Structure Box" on the page.
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<StructureSection load='1itl' size='340' side='right'caption='[[1itl]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1itl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ITL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ITL FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1itl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1itl OCA], [https://pdbe.org/1itl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1itl RCSB], [https://www.ebi.ac.uk/pdbsum/1itl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1itl ProSAT]</span></td></tr>
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{{STRUCTURE_1itl| PDB=1itl | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/IL4_HUMAN IL4_HUMAN] Genetic variations in IL4 may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:[https://omim.org/entry/601367 601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.<ref>PMID:14681304</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/IL4_HUMAN IL4_HUMAN] Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/it/1itl_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1itl ConSurf].
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<div style="clear:both"></div>
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===HUMAN INTERLEUKIN 4: THE SOLUTION STRUCTURE OF A FOUR-HELIX-BUNDLE PROTEIN===
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==See Also==
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*[[Interleukin 3D structures|Interleukin 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_1569578}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 1569578 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_1569578}}
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==About this Structure==
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1ITL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ITL OCA].
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==Reference==
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Human interleukin 4. The solution structure of a four-helix bundle protein., Smith LJ, Redfield C, Boyd J, Lawrence GM, Edwards RG, Smith RA, Dobson CM, J Mol Biol. 1992 Apr 20;224(4):899-904. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1569578 1569578]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Boyd, J.]]
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[[Category: Boyd J]]
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[[Category: Dobson, C M.]]
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[[Category: Dobson CM]]
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[[Category: Edwards, R G.]]
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[[Category: Edwards RG]]
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[[Category: Lawrence, G M.P.]]
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[[Category: Lawrence GMP]]
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[[Category: Redfield, C.]]
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[[Category: Redfield C]]
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[[Category: Smith, L J.]]
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[[Category: Smith LJ]]
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[[Category: Smith, R A.G.]]
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[[Category: Smith RAG]]
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[[Category: Cytokine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 13:58:42 2008''
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Current revision

HUMAN INTERLEUKIN 4: THE SOLUTION STRUCTURE OF A FOUR-HELIX-BUNDLE PROTEIN

PDB ID 1itl

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