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1j7l

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{{Seed}}
 
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[[Image:1j7l.png|left|200px]]
 
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==Crystal Structure of 3',5"-Aminoglycoside Phosphotransferase Type IIIa ADP Complex==
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The line below this paragraph, containing "STRUCTURE_1j7l", creates the "Structure Box" on the page.
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<StructureSection load='1j7l' size='340' side='right'caption='[[1j7l]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1j7l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J7L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1J7L FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_1j7l| PDB=1j7l | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1j7l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j7l OCA], [https://pdbe.org/1j7l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1j7l RCSB], [https://www.ebi.ac.uk/pdbsum/1j7l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1j7l ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KKA3_ENTFL KKA3_ENTFL] Resistance to kanamycin and structurally-related aminoglycosides, including amikacin.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j7/1j7l_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1j7l ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of 3',5"-Aminoglycoside Phosphotransferase Type IIIa ADP Complex===
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==See Also==
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*[[Phosphotransferase 3D structures|Phosphotransferase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_11467935}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11467935 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11467935}}
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==About this Structure==
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1J7L is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J7L OCA].
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==Reference==
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Structural analyses of nucleotide binding to an aminoglycoside phosphotransferase., Burk DL, Hon WC, Leung AK, Berghuis AM, Biochemistry. 2001 Jul 31;40(30):8756-64. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11467935 11467935]
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[[Category: Enterococcus faecalis]]
[[Category: Enterococcus faecalis]]
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[[Category: Kanamycin kinase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Berghuis AM]]
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[[Category: Berghuis, A M.]]
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[[Category: Burk DL]]
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[[Category: Burk, D L.]]
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[[Category: Hon WC]]
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[[Category: Hon, W C.]]
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[[Category: Leung AK-W]]
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[[Category: Leung, A K.W.]]
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[[Category: Antibiotic resistance]]
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[[Category: Atp-binding]]
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[[Category: Kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 14:35:41 2008''
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Current revision

Crystal Structure of 3',5"-Aminoglycoside Phosphotransferase Type IIIa ADP Complex

PDB ID 1j7l

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