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1j7v

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(New page: 200px<br /> <applet load="1j7v" size="450" color="white" frame="true" align="right" spinBox="true" caption="1j7v, resolution 2.9&Aring;" /> '''HUMAN IL-10 / IL-10R...)
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[[Image:1j7v.gif|left|200px]]<br />
 
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<applet load="1j7v" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1j7v, resolution 2.9&Aring;" />
 
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'''HUMAN IL-10 / IL-10R1 COMPLEX'''<br />
 
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==Overview==
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==HUMAN IL-10 / IL-10R1 COMPLEX==
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Interleukin 10 (IL-10) is a dimeric cytokine that plays a central role in, suppressing inflammatory responses. These activities are dependent on the, interaction of IL-10 with its high-affinity receptor (IL-10R1). This, intermediate complex must subsequently recruit the low-affinity IL-10R2, chain before cell signaling can occur. Here we report the 2.9 A crystal, structure of IL-10 bound to a soluble form of IL-10R1 (sIL-10R1). The, complex consists of two IL-10s and four sIL-10R1 molecules. Several, residues in the IL-10/sIL-10R1 interface are conserved in all IL-10, homologs and their receptors. The data suggests that formation of the, active IL-10 signaling complex occurs by a novel molecular recognition, paradigm where IL-10R1 and IL-10R2 both recognize the same binding site on, IL-10.
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<StructureSection load='1j7v' size='340' side='right'caption='[[1j7v]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1j7v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J7V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1J7V FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1j7v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j7v OCA], [https://pdbe.org/1j7v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1j7v RCSB], [https://www.ebi.ac.uk/pdbsum/1j7v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1j7v ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IL10_HUMAN IL10_HUMAN] Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j7/1j7v_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1j7v ConSurf].
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<div style="clear:both"></div>
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==Disease==
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==See Also==
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Known diseases associated with this structure: Graft-versus-host disease, protection against OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=124092 124092]], HIV-1, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=124092 124092]], Rheumatoid arthritis, progression of OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=124092 124092]]
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*[[Interleukin 3D structures|Interleukin 3D structures]]
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*[[Interleukin receptor 3D structures|Interleukin receptor 3D structures]]
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==About this Structure==
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__TOC__
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1J7V is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1J7V OCA].
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</StructureSection>
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==Reference==
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Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site., Josephson K, Logsdon NJ, Walter MR, Immunity. 2001 Jul;15(1):35-46. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11485736 11485736]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Josephson, K.]]
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[[Category: Josephson K]]
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[[Category: Logsdon, N.]]
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[[Category: Logsdon N]]
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[[Category: Walter, M.R.]]
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[[Category: Walter MR]]
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[[Category: 4 helix bundle]]
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[[Category: class 2 receptor]]
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[[Category: cytokine receptor complex]]
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[[Category: interleukin-10]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 17:37:58 2007''
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Current revision

HUMAN IL-10 / IL-10R1 COMPLEX

PDB ID 1j7v

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