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1j8e

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[[Image:1j8e.png|left|200px]]
 
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{{STRUCTURE_1j8e| PDB=1j8e | SCENE= }}
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==Crystal structure of ligand-binding repeat CR7 from LRP==
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<StructureSection load='1j8e' size='340' side='right'caption='[[1j8e]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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===Crystal structure of ligand-binding repeat CR7 from LRP===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1j8e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J8E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1J8E FirstGlance]. <br>
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{{ABSTRACT_PUBMED_11735395}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1j8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j8e OCA], [https://pdbe.org/1j8e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1j8e RCSB], [https://www.ebi.ac.uk/pdbsum/1j8e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1j8e ProSAT]</span></td></tr>
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[[1j8e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J8E OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/LRP1_HUMAN LRP1_HUMAN] Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission.<ref>PMID:1702392</ref> <ref>PMID:1618748</ref> <ref>PMID:11907044</ref> <ref>PMID:12888553</ref> <ref>PMID:12713657</ref> Functions as a receptor for Pseudomonas aeruginosa exotoxin A.<ref>PMID:1702392</ref> <ref>PMID:1618748</ref> <ref>PMID:11907044</ref> <ref>PMID:12888553</ref> <ref>PMID:12713657</ref>
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<ref group="xtra">PMID:011735395</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j8/1j8e_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1j8e ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Dolmer, K.]]
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[[Category: Large Structures]]
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[[Category: Gettins, P G.W.]]
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[[Category: Dolmer K]]
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[[Category: Huang, W.]]
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[[Category: Gettins PGW]]
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[[Category: Simonovic, M.]]
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[[Category: Huang W]]
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[[Category: Strickland, D K.]]
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[[Category: Simonovic M]]
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[[Category: Volz, K.]]
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[[Category: Strickland DK]]
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[[Category: Calcium binding]]
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[[Category: Volz K]]
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[[Category: Complement-like repeat]]
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[[Category: Ligand binding]]
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[[Category: Lrp receptor]]
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[[Category: Signaling protein]]
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Current revision

Crystal structure of ligand-binding repeat CR7 from LRP

PDB ID 1j8e

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