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1j8e

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{{Seed}}
 
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[[Image:1j8e.png|left|200px]]
 
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==Crystal structure of ligand-binding repeat CR7 from LRP==
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The line below this paragraph, containing "STRUCTURE_1j8e", creates the "Structure Box" on the page.
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<StructureSection load='1j8e' size='340' side='right'caption='[[1j8e]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1j8e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J8E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1J8E FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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{{STRUCTURE_1j8e| PDB=1j8e | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1j8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j8e OCA], [https://pdbe.org/1j8e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1j8e RCSB], [https://www.ebi.ac.uk/pdbsum/1j8e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1j8e ProSAT]</span></td></tr>
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</table>
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===Crystal structure of ligand-binding repeat CR7 from LRP===
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== Function ==
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[https://www.uniprot.org/uniprot/LRP1_HUMAN LRP1_HUMAN] Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission.<ref>PMID:1702392</ref> <ref>PMID:1618748</ref> <ref>PMID:11907044</ref> <ref>PMID:12888553</ref> <ref>PMID:12713657</ref> Functions as a receptor for Pseudomonas aeruginosa exotoxin A.<ref>PMID:1702392</ref> <ref>PMID:1618748</ref> <ref>PMID:11907044</ref> <ref>PMID:12888553</ref> <ref>PMID:12713657</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_11735395}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 11735395 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j8/1j8e_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_11735395}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1J8E is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J8E OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1j8e ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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<ref group="xtra">PMID:11735395</ref><references group="xtra"/>
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Dolmer, K.]]
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[[Category: Large Structures]]
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[[Category: Gettins, P G.W.]]
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[[Category: Dolmer K]]
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[[Category: Huang, W.]]
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[[Category: Gettins PGW]]
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[[Category: Simonovic, M.]]
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[[Category: Huang W]]
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[[Category: Strickland, D K.]]
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[[Category: Simonovic M]]
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[[Category: Volz, K.]]
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[[Category: Strickland DK]]
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[[Category: Calcium binding]]
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[[Category: Volz K]]
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[[Category: Complement-like repeat]]
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[[Category: Ligand binding]]
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[[Category: Lrp receptor]]
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[[Category: Signaling protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 04:42:07 2009''
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Current revision

Crystal structure of ligand-binding repeat CR7 from LRP

PDB ID 1j8e

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