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1j8s

From Proteopedia

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(New page: 200px <!-- The line below this paragraph, containing "STRUCTURE_1j8s", creates the "Structure Box" on the page. You may change the PDB parameter (which sets the PD...)
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[[Image:1j8s.png|left|200px]]
 
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==PAPG ADHESIN RECEPTOR BINDING DOMAIN-UNBOUND FORM==
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The line below this paragraph, containing "STRUCTURE_1j8s", creates the "Structure Box" on the page.
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<StructureSection load='1j8s' size='340' side='right'caption='[[1j8s]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1j8s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J8S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1J8S FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_1j8s| PDB=1j8s | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1j8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j8s OCA], [https://pdbe.org/1j8s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1j8s RCSB], [https://www.ebi.ac.uk/pdbsum/1j8s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1j8s ProSAT]</span></td></tr>
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</table>
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===PAPG ADHESIN RECEPTOR BINDING DOMAIN-UNBOUND FORM===
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== Function ==
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[https://www.uniprot.org/uniprot/PAPG2_ECOLX PAPG2_ECOLX] Tip adhesin component of type P pili that plays a critical role in kidney infection through targeted interaction with the globoseries glycolipids containing the Gal-alpha(1-4)-Gal disaccharide present on uroepithelial cells (PubMed:11440716, PubMed:31361021). In turn, transcriptionally regulates host gene expression in kidney cells, leading to inflammatory pathway activation and renal tissue damage. Acts thereby as key determinant of invasive uropathogenic E.coli (UPEC), which cause pyelonephritis and urinary-source bacteremia (By similarity).[UniProtKB:A0A0H2VAQ6]<ref>PMID:11440716</ref> <ref>PMID:31361021</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_11440716}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 11440716 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j8/1j8s_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_11440716}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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[[1j8s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J8S OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1j8s ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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<ref group="xtra">PMID:011440716</ref><references group="xtra"/>
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<references/>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Dodson, K W.]]
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[[Category: Large Structures]]
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[[Category: Hultgren, S J.]]
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[[Category: Dodson KW]]
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[[Category: Magnusson, G.]]
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[[Category: Hultgren SJ]]
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[[Category: Pinkner, J S.]]
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[[Category: Magnusson G]]
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[[Category: Rose, T.]]
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[[Category: Pinkner JS]]
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[[Category: Waksman, G.]]
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[[Category: Rose T]]
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[[Category: Papg adhesin]]
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[[Category: Waksman G]]
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[[Category: Receptor]]
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[[Category: Structural protein]]
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Current revision

PAPG ADHESIN RECEPTOR BINDING DOMAIN-UNBOUND FORM

PDB ID 1j8s

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