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1je4

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{{Seed}}
 
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[[Image:1je4.png|left|200px]]
 
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==Solution structure of the monomeric variant of the chemokine MIP-1beta==
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The line below this paragraph, containing "STRUCTURE_1je4", creates the "Structure Box" on the page.
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<StructureSection load='1je4' size='340' side='right'caption='[[1je4]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1je4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JE4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JE4 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1je4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1je4 OCA], [https://pdbe.org/1je4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1je4 RCSB], [https://www.ebi.ac.uk/pdbsum/1je4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1je4 ProSAT]</span></td></tr>
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{{STRUCTURE_1je4| PDB=1je4 | SCENE= }}
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</table>
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== Function ==
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===Solution structure of the monomeric variant of the chemokine MIP-1beta===
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[https://www.uniprot.org/uniprot/CCL4_HUMAN CCL4_HUMAN] Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.<ref>PMID:8525373</ref> <ref>PMID:10540332</ref> <ref>PMID:12070155</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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<!--
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_11535053}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 11535053 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/je/1je4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_11535053}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1je4 ConSurf].
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1JE4 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JE4 OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:11535053</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Jao, S.]]
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[[Category: Large Structures]]
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[[Category: Kim, S.]]
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[[Category: Jao S]]
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[[Category: Laurence, J S.]]
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[[Category: Kim S]]
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[[Category: LiWang, P J.]]
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[[Category: Laurence JS]]
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[[Category: Chemokine]]
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[[Category: LiWang PJ]]
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[[Category: Macrophage inflammatory protein]]
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[[Category: Mip-1beta]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 10:20:48 2009''
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Current revision

Solution structure of the monomeric variant of the chemokine MIP-1beta

PDB ID 1je4

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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