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1jfm

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(New page: 200px<br /><applet load="1jfm" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jfm, resolution 2.85&Aring;" /> '''CRYSTAL STRUCTURE OF...)
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[[Image:1jfm.jpg|left|200px]]<br /><applet load="1jfm" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1jfm, resolution 2.85&Aring;" />
 
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'''CRYSTAL STRUCTURE OF MURINE NK CELL LIGAND RAE-1 BETA'''<br />
 
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==Overview==
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==CRYSTAL STRUCTURE OF MURINE NK CELL LIGAND RAE-1 BETA==
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Induced by retinoic acid and implicated in playing a role in development, rodent RAE-1 proteins are ligands for the activating immunoreceptor NKG2D, widely expressed on natural killer cells, T cells, and macrophages. RAE-1, proteins (alpha, beta, gamma, and delta) are distant major, histocompatibility complex (MHC) class I homologs, comprising isolated, alpha1alpha2 platform domains. The crystal structure of RAE-1beta was, distorted from other MHC homologs and displayed noncanonical disulfide, bonds. The loss of any remnant of a peptide binding groove was facilitated, by the close approach of the groove-defining helices through a, hydrophobic, leucine-rich interface. The RAE-1beta-murine NKG2D complex, structure resembled the human NKG2D-MICA receptor-ligand complex and, further demonstrated the promiscuity of the NKG2D ligand binding site.
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<StructureSection load='1jfm' size='340' side='right'caption='[[1jfm]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1jfm]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JFM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JFM FirstGlance]. <br>
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1JFM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1JFM OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jfm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jfm OCA], [https://pdbe.org/1jfm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jfm RCSB], [https://www.ebi.ac.uk/pdbsum/1jfm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jfm ProSAT]</span></td></tr>
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==Reference==
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</table>
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Crystal structures of RAE-1beta and its complex with the activating immunoreceptor NKG2D., Li P, McDermott G, Strong RK, Immunity. 2002 Jan;16(1):77-86. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11825567 11825567]
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== Function ==
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[https://www.uniprot.org/uniprot/RAE1B_MOUSE RAE1B_MOUSE] Acts as a ligand for NKG2D.<ref>PMID:10894171</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jf/1jfm_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jfm ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Li P]]
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[[Category: Li, P.]]
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[[Category: Strong RK]]
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[[Category: Strong, R.K.]]
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[[Category: mhc-i platform]]
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[[Category: murine nk cell ligand]]
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[[Category: nkg2d]]
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[[Category: rae-1 beta]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 18:12:07 2007''
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Current revision

CRYSTAL STRUCTURE OF MURINE NK CELL LIGAND RAE-1 BETA

PDB ID 1jfm

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