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1jgm

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{{Seed}}
 
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[[Image:1jgm.png|left|200px]]
 
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==High Resolution Structure of the Cadmium-containing Phosphotriesterase from Pseudomonas diminuta==
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The line below this paragraph, containing "STRUCTURE_1jgm", creates the "Structure Box" on the page.
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<StructureSection load='1jgm' size='340' side='right'caption='[[1jgm]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1jgm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Brevundimonas_diminuta Brevundimonas diminuta]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1i03 1i03]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JGM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JGM FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEL:2-PHENYL-ETHANOL'>PEL</scene></td></tr>
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{{STRUCTURE_1jgm| PDB=1jgm | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jgm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jgm OCA], [https://pdbe.org/1jgm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jgm RCSB], [https://www.ebi.ac.uk/pdbsum/1jgm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jgm ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/OPD_BREDI OPD_BREDI] Has an unusual substrate specificity for synthetic organophosphate triesters and phosphorofluoridates. All of the phosphate triesters found to be substrates are synthetic compounds. The identity of any naturally occurring substrate for the enzyme is unknown. Has no detectable activity with phosphate monoesters or diesters and no activity as an esterase or protease. It catalyzes the hydrolysis of the insecticide paraoxon at a rate approaching the diffusion limit and thus appears to be optimally evolved for utilizing this synthetic substrate.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jg/1jgm_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jgm ConSurf].
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<div style="clear:both"></div>
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===High Resolution Structure of the Cadmium-containing Phosphotriesterase from Pseudomonas diminuta===
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==See Also==
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*[[Phosphotriesterase 3D structures|Phosphotriesterase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_11258882}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11258882 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11258882}}
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==About this Structure==
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1JGM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Brevundimonas_diminuta Brevundimonas diminuta]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1i03 1i03]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JGM OCA].
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==Reference==
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High resolution X-ray structures of different metal-substituted forms of phosphotriesterase from Pseudomonas diminuta., Benning MM, Shim H, Raushel FM, Holden HM, Biochemistry. 2001 Mar 6;40(9):2712-22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11258882 11258882]
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[[Category: Aryldialkylphosphatase]]
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[[Category: Brevundimonas diminuta]]
[[Category: Brevundimonas diminuta]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Benning, M M.]]
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[[Category: Benning MM]]
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[[Category: Holden, H M.]]
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[[Category: Holden HM]]
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[[Category: Raushel, F M.]]
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[[Category: Raushel FM]]
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[[Category: Shim, H.]]
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[[Category: Shim H]]
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[[Category: Cadmium]]
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[[Category: Hydrolase]]
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[[Category: Pte]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:12:50 2008''
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Current revision

High Resolution Structure of the Cadmium-containing Phosphotriesterase from Pseudomonas diminuta

PDB ID 1jgm

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