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1ji8

From Proteopedia

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(New page: 200px<br /><applet load="1ji8" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ji8" /> '''Solution Structure of Pyrobaculum Aerophilum...)
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[[Image:1ji8.gif|left|200px]]<br /><applet load="1ji8" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1ji8" />
 
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'''Solution Structure of Pyrobaculum Aerophilum DsrC/gamma subunit of dissimilatory sulfite reductase'''<br />
 
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==Overview==
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==Solution Structure of Pyrobaculum Aerophilum DsrC/gamma subunit of dissimilatory sulfite reductase==
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The solution structure of DsrC, an archaeal homologue of the gamma subunit, of dissimilatory sulfite reductase, has been determined by NMR, spectroscopy. This 12.7-kDa protein from the hyperthermophilic archaeon, Pyrobaculum aerophilum adopts a novel fold consisting of an orthogonal, helical bundle with a beta hairpin along one side. A portion of the, structure resembles the helix-turn-helix DNA-binding motif common in, transcriptional regulator proteins. The protein contains two disulfide, bonds but remains folded following reduction of the disulfides. DsrC, proteins from organisms other than Pyrobaculum species do not contain, these disulfide bonds. A conserved cysteine next to the C-terminus, which, is not involved in the disulfide bonds, is located on a seven-residue, C-terminal arm that is not part of the globular protein and is likely to, dynamically sample more than one conformation.
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<StructureSection load='1ji8' size='340' side='right'caption='[[1ji8]]' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1ji8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrobaculum_aerophilum Pyrobaculum aerophilum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JI8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JI8 FirstGlance]. <br>
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1JI8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pyrobaculum_aerophilum Pyrobaculum aerophilum]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1JI8 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ji8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ji8 OCA], [https://pdbe.org/1ji8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ji8 RCSB], [https://www.ebi.ac.uk/pdbsum/1ji8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ji8 ProSAT], [https://www.topsan.org/Proteins/NESGC/1ji8 TOPSAN]</span></td></tr>
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==Reference==
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</table>
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Solution structure of Pyrobaculum aerophilum DsrC, an archaeal homologue of the gamma subunit of dissimilatory sulfite reductase., Cort JR, Mariappan SV, Kim CY, Park MS, Peat TS, Waldo GS, Terwilliger TC, Kennedy MA, Eur J Biochem. 2001 Nov;268(22):5842-50. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11722571 11722571]
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== Function ==
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[https://www.uniprot.org/uniprot/Q8ZUX1_PYRAE Q8ZUX1_PYRAE]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ji/1ji8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ji8 ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Pyrobaculum aerophilum]]
[[Category: Pyrobaculum aerophilum]]
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[[Category: Single protein]]
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[[Category: Cort JR]]
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[[Category: Cort, J.R.]]
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[[Category: Kennedy MA]]
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[[Category: Kennedy, M.A.]]
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[[Category: NESG, Northeast.Structural.Genomics.Consortium.]]
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[[Category: nesg]]
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[[Category: northeast structural genomics consortium]]
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[[Category: orthogonal helical bundle]]
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[[Category: protein structure initiative]]
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[[Category: psi]]
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[[Category: structural genomics]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sat Nov 24 23:40:38 2007''
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Current revision

Solution Structure of Pyrobaculum Aerophilum DsrC/gamma subunit of dissimilatory sulfite reductase

PDB ID 1ji8

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