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1jmm

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(New page: 200px<br /><applet load="1jmm" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jmm, resolution 2.40&Aring;" /> '''Crystal structure of...)
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[[Image:1jmm.jpg|left|200px]]<br /><applet load="1jmm" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1jmm, resolution 2.40&Aring;" />
 
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'''Crystal structure of the V-region of Streptococcus mutans antigen I/II'''<br />
 
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==Overview==
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==Crystal structure of the V-region of Streptococcus mutans antigen I/II==
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Antigens I/II are large multifunctional adhesins from oral viridans, streptococci that exert immunomodulatory effects on human cells and play, important roles in inflammatory disorders. Among them, Streptococcus, mutans plays a major role in the initiation of dental caries. The, structure of the V-region (SrV+, residues 464-840) of the antigen I/II of, S. mutans has been determined using the multiwavelength anomalous, diffraction phasing technique with seleno-methionine-substituted, recombinant protein and subsequently refined at 2.4 A resolution. The, crystal structure of SrV+ revealed a lectin-like fold that displays a, putative preformed carbohydrate-binding site stabilized by a metal ion., Inhibition of this binding site may confer to humans a protection against, dental caries and dissemination of the bacteria to extra-oral sites, involved in life-threatening inflammatory diseases. This crystal structure, constitutes a first step in understanding the structure-function, relationship of antigens I/II and may help in delineating new preventive, or therapeutic strategies against colonization of the host by oral, streptococci.
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<StructureSection load='1jmm' size='340' side='right'caption='[[1jmm]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1jmm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_mutans Streptococcus mutans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JMM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JMM FirstGlance]. <br>
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1JMM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_mutans Streptococcus mutans] with NA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1JMM OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jmm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jmm OCA], [https://pdbe.org/1jmm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jmm RCSB], [https://www.ebi.ac.uk/pdbsum/1jmm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jmm ProSAT]</span></td></tr>
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Crystal structure of the V-region of Streptococcus mutans antigen I/II at 2.4 A resolution suggests a sugar preformed binding site., Troffer-Charlier N, Ogier J, Moras D, Cavarelli J, J Mol Biol. 2002 Apr 19;318(1):179-88. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12054777 12054777]
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</table>
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[[Category: Single protein]]
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== Function ==
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[https://www.uniprot.org/uniprot/PAC_STRMG PAC_STRMG] Surface protein antigen implicated in dental caries.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jm/1jmm_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jmm ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Streptococcus mutans]]
[[Category: Streptococcus mutans]]
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[[Category: Cavarelli, J.]]
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[[Category: Cavarelli J]]
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[[Category: Moras, D.]]
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[[Category: Moras D]]
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[[Category: Ogier, J.]]
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[[Category: Ogier J]]
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[[Category: Troffer-Charlier, N.]]
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[[Category: Troffer-Charlier N]]
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[[Category: NA]]
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[[Category: antigen i/ii]]
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[[Category: v-region]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 18:22:51 2007''
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Current revision

Crystal structure of the V-region of Streptococcus mutans antigen I/II

PDB ID 1jmm

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