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1jmz

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(New page: 200px<br /><applet load="1jmz" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jmz, resolution 2.0&Aring;" /> '''crystal structure of ...)
Current revision (07:53, 3 April 2024) (edit) (undo)
 
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[[Image:1jmz.jpg|left|200px]]<br /><applet load="1jmz" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1jmz, resolution 2.0&Aring;" />
 
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'''crystal structure of a quinohemoprotein amine dehydrogenase from pseudomonas putida with inhibitor'''<br />
 
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==Overview==
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==crystal structure of a quinohemoprotein amine dehydrogenase from pseudomonas putida with inhibitor==
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The crystal structure of a quinohemoprotein amine dehydrogenase from, Pseudomonas putida has been determined at 1.9-A resolution. The enzyme, comprises three non-identical subunits: a four-domain alpha-subunit that, harbors a di-heme cytochrome c, a seven-bladed beta-propeller beta-subunit, that provides part of the active site, and a small gamma-subunit that, contains a novel cross-linked, proteinous quinone cofactor, cysteine, tryptophylquinone. More surprisingly, the catalytic gamma-subunit contains, three additional chemical cross-links that encage the cysteine, tryptophylquinone cofactor, involving a cysteine side chain bridged to, either an Asp or Glu residue all in a hitherto unknown thioether bonding, with a methylene carbon atom of acidic amino acid side chains. Thus, the, structure of the 79-residue gamma-subunit is quite unusual, containing, four internal cross-links in such a short polypeptide chain that would, otherwise be difficult to fold into a globular structure.
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<StructureSection load='1jmz' size='340' side='right'caption='[[1jmz]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1jmz]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_putida Pseudomonas putida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JMZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JMZ FirstGlance]. <br>
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1JMZ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Pseudomonas_putida Pseudomonas putida] with NI, PND and HEC as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1JMZ OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEC:HEME+C'>HEC</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PND:P-NITROPHENYLHYDRAZINE'>PND</scene>, <scene name='pdbligand=TRQ:2-AMINO-3-(6,7-DIOXO-6,7-DIHYDRO-1H-INDOL-3-YL)-PROPIONIC+ACID'>TRQ</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jmz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jmz OCA], [https://pdbe.org/1jmz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jmz RCSB], [https://www.ebi.ac.uk/pdbsum/1jmz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jmz ProSAT]</span></td></tr>
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Crystal structure of quinohemoprotein amine dehydrogenase from Pseudomonas putida. Identification of a novel quinone cofactor encaged by multiple thioether cross-bridges., Satoh A, Kim JK, Miyahara I, Devreese B, Vandenberghe I, Hacisalihoglu A, Okajima T, Kuroda S, Adachi O, Duine JA, Van Beeumen J, Tanizawa K, Hirotsu K, J Biol Chem. 2002 Jan 25;277(4):2830-4. Epub 2001 Nov 9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11704672 11704672]
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</table>
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[[Category: Protein complex]]
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== Function ==
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[https://www.uniprot.org/uniprot/Q8VW85_PSEPU Q8VW85_PSEPU]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jm/1jmz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jmz ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Pseudomonas putida]]
[[Category: Pseudomonas putida]]
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[[Category: Hirotsu, K.]]
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[[Category: Hirotsu K]]
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[[Category: Miyahara, I.]]
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[[Category: Miyahara I]]
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[[Category: Satoh, A.]]
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[[Category: Satoh A]]
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[[Category: HEC]]
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[[Category: NI]]
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[[Category: PND]]
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[[Category: amine dehydrogenase]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 18:23:28 2007''
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Current revision

crystal structure of a quinohemoprotein amine dehydrogenase from pseudomonas putida with inhibitor

PDB ID 1jmz

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