1jpy

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[[Image:1jpy.png|left|200px]]
 
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{{STRUCTURE_1jpy| PDB=1jpy | SCENE= }}
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==Crystal structure of IL-17F==
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<StructureSection load='1jpy' size='340' side='right'caption='[[1jpy]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
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===Crystal structure of IL-17F===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1jpy]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JPY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JPY FirstGlance]. <br>
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{{ABSTRACT_PUBMED_11574464}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jpy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jpy OCA], [https://pdbe.org/1jpy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jpy RCSB], [https://www.ebi.ac.uk/pdbsum/1jpy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jpy ProSAT]</span></td></tr>
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[[1jpy]] is a 4 chain structure of [[Interleukin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JPY OCA].
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/IL17F_HUMAN IL17F_HUMAN] Defects in IL17F are the cause of familial candidiasis type 6 (CANDF6) [MIM:[https://omim.org/entry/613956 613956]. CANDF6 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.<ref>PMID:21350122</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/IL17F_HUMAN IL17F_HUMAN] Stimulates the production of other cytokines such as IL-6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. Stimulates PBMC and T-cell proliferation. Inhibits angiogenesis.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jp/1jpy_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jpy ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Interleukin|Interleukin]]
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*[[Interleukin 3D structures|Interleukin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:011574464</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Cai, L.]]
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[[Category: Large Structures]]
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[[Category: Filvaroff, E H.]]
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[[Category: Cai L]]
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[[Category: Foster, J.]]
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[[Category: Filvaroff EH]]
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[[Category: Gurney, A L.]]
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[[Category: Foster J]]
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[[Category: Hymowitz, S G.]]
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[[Category: Gurney AL]]
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[[Category: Kelley, R.]]
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[[Category: Hymowitz SG]]
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[[Category: Lee, J.]]
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[[Category: Kelley R]]
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[[Category: Mao, W.]]
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[[Category: Lee J]]
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[[Category: Maruoka, M.]]
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[[Category: Mao W]]
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[[Category: Pan, G.]]
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[[Category: Maruoka M]]
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[[Category: Risser, P.]]
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[[Category: Pan G]]
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[[Category: Starovasnik, M A.]]
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[[Category: Risser P]]
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[[Category: Vos, A M.de.]]
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[[Category: Starovasnik MA]]
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[[Category: Yin, J.]]
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[[Category: Yin J]]
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[[Category: Cystine-knot]]
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[[Category: De Vos AM]]
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[[Category: Cytokine]]
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[[Category: Dimer]]
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[[Category: Immune system]]
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[[Category: T-cell derived]]
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Current revision

Crystal structure of IL-17F

PDB ID 1jpy

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