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1jr8

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[[Image:1jr8.jpg|left|200px]]
 
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==Crystal Structure of Erv2p==
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The line below this paragraph, containing "STRUCTURE_1jr8", creates the "Structure Box" on the page.
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<StructureSection load='1jr8' size='340' side='right'caption='[[1jr8]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1jr8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JR8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JR8 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
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{{STRUCTURE_1jr8| PDB=1jr8 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jr8 OCA], [https://pdbe.org/1jr8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jr8 RCSB], [https://www.ebi.ac.uk/pdbsum/1jr8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jr8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ERV2_YEAST ERV2_YEAST] FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation in the endoplasmic reticulum lumen in parallel to ERO1.<ref>PMID:11313344</ref> <ref>PMID:11584268</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jr/1jr8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jr8 ConSurf].
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<div style="clear:both"></div>
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'''Crystal Structure of Erv2p'''
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==See Also==
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*[[Sulfhydryl oxidase 3D structures|Sulfhydryl oxidase 3D structures]]
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== References ==
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==Overview==
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<references/>
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Erv2p is an FAD-dependent sulfhydryl oxidase that can promote disulfide bond formation during protein biosynthesis in the yeast endoplasmic reticulum. The structure of Erv2p, determined by X-ray crystallography to 1.5 A resolution, reveals a helix-rich dimer with no global resemblance to other known FAD-binding proteins or thiol oxidoreductases. Two pairs of cysteine residues are required for Erv2p activity. The first (Cys-Gly-Glu-Cys) is adjacent to the isoalloxazine ring of the FAD. The second (Cys-Gly-Cys) is part of a flexible C-terminal segment that can swing into the vicinity of the first cysteine pair in the opposite subunit of the dimer and may shuttle electrons between substrate protein dithiols and the FAD-proximal disulfide.
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1JR8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JR8 OCA].
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==Reference==
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A new FAD-binding fold and intersubunit disulfide shuttle in the thiol oxidase Erv2p., Gross E, Sevier CS, Vala A, Kaiser CA, Fass D, Nat Struct Biol. 2002 Jan;9(1):61-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11740506 11740506]
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Single protein]]
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[[Category: Fass D]]
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[[Category: Fass, D.]]
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[[Category: Gross E]]
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[[Category: Gross, E.]]
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[[Category: Kaiser CA]]
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[[Category: Kaiser, C A.]]
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[[Category: Sevier CS]]
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[[Category: Sevier, C S.]]
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[[Category: Vala A]]
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[[Category: Vala, A.]]
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[[Category: Cxxc]]
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[[Category: Fad]]
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[[Category: Helical bundle]]
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[[Category: Sulfhydryl oxidase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:44:07 2008''
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Current revision

Crystal Structure of Erv2p

PDB ID 1jr8

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