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1jrr

From Proteopedia

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{{Seed}}
 
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[[Image:1jrr.png|left|200px]]
 
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==HUMAN PLASMINOGEN ACTIVATOR INHIBITOR-2.[LOOP (66-98) DELETIONMUTANT] COMPLEXED WITH PEPTIDE MIMIckING THE REACTIVE CENTER LOOP==
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The line below this paragraph, containing "STRUCTURE_1jrr", creates the "Structure Box" on the page.
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<StructureSection load='1jrr' size='340' side='right'caption='[[1jrr]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1jrr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JRR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JRR FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene></td></tr>
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{{STRUCTURE_1jrr| PDB=1jrr | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jrr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jrr OCA], [https://pdbe.org/1jrr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jrr RCSB], [https://www.ebi.ac.uk/pdbsum/1jrr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jrr ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PAI2_HUMAN PAI2_HUMAN] Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jr/1jrr_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jrr ConSurf].
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<div style="clear:both"></div>
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===HUMAN PLASMINOGEN ACTIVATOR INHIBITOR-2.[LOOP (66-98) DELETIONMUTANT] COMPLEXED WITH PEPTIDE MIMIckING THE REACTIVE CENTER LOOP===
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==See Also==
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*[[Plasminogen activator inhibitor|Plasminogen activator inhibitor]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_11546761}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11546761 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11546761}}
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==About this Structure==
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1JRR is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JRR OCA].
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==Reference==
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<ref group="xtra">PMID:11546761</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Andrews, J L.]]
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[[Category: Large Structures]]
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[[Category: Baker, M S.]]
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[[Category: Andrews JL]]
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[[Category: Bertram, K C.]]
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[[Category: Baker MS]]
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[[Category: Curmi, P M.G.]]
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[[Category: Bertram KC]]
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[[Category: Gould, A R.]]
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[[Category: Curmi PMG]]
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[[Category: Harrop, S J.]]
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[[Category: Gould AR]]
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[[Category: Jankova, L.]]
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[[Category: Harrop SJ]]
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[[Category: Saunders, D N.]]
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[[Category: Jankova L]]
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[[Category: Peptide binding]]
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[[Category: Saunders DN]]
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[[Category: Serpin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 05:46:53 2009''
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Current revision

HUMAN PLASMINOGEN ACTIVATOR INHIBITOR-2.[LOOP (66-98) DELETIONMUTANT] COMPLEXED WITH PEPTIDE MIMIckING THE REACTIVE CENTER LOOP

PDB ID 1jrr

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