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1jv2

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CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN ALPHAVBETA3

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@@ Line 1: / Line 1: @@
-[[Image:1jv2.gif|left|200px]]
- {{Structure
+==CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN ALPHAVBETA3==
-|PDB= 1jv2 |SIZE=350|CAPTION= <scene name='initialview01'>1jv2</scene>, resolution 3.1&Aring;
+<StructureSection load='1jv2' size='340' side='right'caption='[[1jv2]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>
+<table><tr><td colspan='2'>[[1jv2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The February 2011 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Integrin''  by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2011_2 10.2210/rcsb_pdb/mom_2011_2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JV2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JV2 FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
-|GENE=
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
-|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=smart00191 Int_alpha], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam08441 Integrin_alpha2], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam07965 Integrin_B_tail], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam00362 Integrin_beta]</span>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jv2 OCA], [https://pdbe.org/1jv2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jv2 RCSB], [https://www.ebi.ac.uk/pdbsum/1jv2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jv2 ProSAT]</span></td></tr>
-|RELATEDENTRY=
+</table>
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jv2 OCA], [http://www.ebi.ac.uk/pdbsum/1jv2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jv2 RCSB]</span>
+== Function ==
-}}
+[https://www.uniprot.org/uniprot/ITAV_HUMAN ITAV_HUMAN] The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jv/1jv2_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jv2 ConSurf].
+<div style="clear:both"></div>
-'''CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN ALPHAVBETA3'''
+==See Also==
+*[[Integrin 3D structures|Integrin 3D structures]]
+__TOC__
-==Overview==
+</StructureSection>
-Integrins are alphabeta heterodimeric receptors that mediate divalent cation-dependent cell-cell and cell-matrix adhesion through tightly regulated interactions with ligands. We have solved the crystal structure of the extracellular portion of integrin alphaVbeta3 at 3.1 A resolution. Its 12 domains assemble into an ovoid "head" and two "tails." In the crystal, alphaVbeta3 is severely bent at a defined region in its tails, reflecting an unusual flexibility that may be linked to integrin regulation. The main inter-subunit interface lies within the head, between a seven-bladed beta-propeller from alphaV and an A domain from beta3, and bears a striking resemblance to the Galpha/Gbeta interface in G proteins. A metal ion-dependent adhesion site (MIDAS) in the betaA domain is positioned to participate in a ligand-binding interface formed of loops from the propeller and betaA domains. MIDAS lies adjacent to a calcium-binding site with a potential regulatory function.
-==About this Structure==
-JV2 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JV2 OCA].
-==Reference==
-Crystal structure of the extracellular segment of integrin alpha Vbeta3., Xiong JP, Stehle T, Diefenbach B, Zhang R, Dunker R, Scott DL, Joachimiak A, Goodman SL, Arnaout MA, Science. 2001 Oct 12;294(5541):339-45. Epub 2001 Sep 6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11546839 11546839]
 [[Category: Homo sapiens]]
-[[Category: Protein complex]]
+[[Category: Integrin]]
-[[Category: Arnaout, M A.]]
+[[Category: Large Structures]]
-[[Category: Diefenbach, B.]]
+[[Category: RCSB PDB Molecule of the Month]]
-[[Category: Dunker, R.]]
+[[Category: Arnaout MA]]
-[[Category: Goodman, S L.]]
+[[Category: Diefenbach B]]
-[[Category: Joachimiak, A.]]
+[[Category: Dunker R]]
-[[Category: Scott, D.]]
+[[Category: Goodman SL]]
-[[Category: Stehle, T.]]
+[[Category: Joachimiak A]]
-[[Category: Xiong, J P.]]
+[[Category: Scott D]]
-[[Category: Zhang, R.]]
+[[Category: Stehle T]]
-[[Category: a-domain]]
+[[Category: Xiong JP]]
-[[Category: admida]]
+[[Category: Zhang R]]
-[[Category: beta-tail domain]]
-[[Category: cage motif]]
-[[Category: calf domain]]
-[[Category: egf domain]]
-[[Category: genu]]
-[[Category: hybrid domain]]
-[[Category: mida]]
-[[Category: propeller]]
-[[Category: psi domain]]
-[[Category: thigh domain]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:39:26 2008''

1jv2

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CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN ALPHAVBETA3

Structural highlights

Function

Evolutionary Conservation

See Also

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