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1jvk

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(New page: 200px<br /><applet load="1jvk" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jvk, resolution 1.94&Aring;" /> '''THREE-DIMENSIONAL ST...)
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[[Image:1jvk.gif|left|200px]]<br /><applet load="1jvk" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1jvk, resolution 1.94&Aring;" />
 
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'''THREE-DIMENSIONAL STRUCTURE OF AN IMMUNOGLOBULIN LIGHT CHAIN DIMER ACTING AS A LETHAL AMYLOID PRECURSOR'''<br />
 
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==Overview==
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==THREE-DIMENSIONAL STRUCTURE OF AN IMMUNOGLOBULIN LIGHT CHAIN DIMER ACTING AS A LETHAL AMYLOID PRECURSOR==
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The X-ray structure of an immunoglobulin light-chain dimer isolated from, the urine as a "Bence-Jones protein" from a patient with multiple myeloma, and amyloidosis (Sea) was determined at 1.94 A resolution and refined to R, and R(free) factors of 0.22 and 0.25, respectively. This "amyloidogenic", protein crystallized in the orthorhombic P2(1)2(1)2(1) space group with, unit-cell parameters a = 48.28, b = 83.32, c = 112.59 A as determined at, 100 K. In the vital organs (heart and kidneys), the equivalent of the, urinary protein produced fibrillar amyloid deposits which were fatal to, the patient. Compared with the amyloidogenic Mcg light-chain dimer, the, Sea protein was highly soluble in aqueous solutions and only crystallized, at concentrations approaching 100 mg ml(-1). Both the Sea and Mcg proteins, packed into crystals in highly ordered arrangements typical of strongly, diffracting crystals of immunoglobulin fragments. Overall similarities and, significant differences in the three-dimensional structures and, crystalline properties are discussed for the Sea and Mcg Bence-Jones, proteins, which together provide a generalized model of abnormalities, present in lambda chains, facilitating a better understanding of, amyloidosis of light-chain origin (AL).
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<StructureSection load='1jvk' size='340' side='right'caption='[[1jvk]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1jvk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JVK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JVK FirstGlance]. <br>
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1JVK is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1JVK OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.94&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jvk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jvk OCA], [https://pdbe.org/1jvk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jvk RCSB], [https://www.ebi.ac.uk/pdbsum/1jvk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jvk ProSAT]</span></td></tr>
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Three-dimensional structure of an immunoglobulin light-chain dimer with amyloidogenic properties., Bourne PC, Ramsland PA, Shan L, Fan ZC, DeWitt CR, Shultz BB, Terzyan SS, Moomaw CR, Slaughter CA, Guddat LW, Edmundson AB, Acta Crystallogr D Biol Crystallogr. 2002 May;58(Pt 5):815-23. Epub 2002, Apr 26. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11976493 11976493]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q6PJG0_HUMAN Q6PJG0_HUMAN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jv/1jvk_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jvk ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Bourne, P.C.]]
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[[Category: Bourne PC]]
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[[Category: DeWitt, C.R.]]
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[[Category: DeWitt CR]]
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[[Category: Edmundson, A.B.]]
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[[Category: Edmundson AB]]
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[[Category: Fan, Z.C.]]
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[[Category: Fan Z-C]]
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[[Category: Ramsland, P.A.]]
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[[Category: Ramsland PA]]
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[[Category: Shan, L.]]
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[[Category: Shan L]]
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[[Category: Shultz, B.B.]]
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[[Category: Shultz BB]]
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[[Category: Terzyan, S.S.]]
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[[Category: Terzyan SS]]
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[[Category: amyloidogenic]]
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[[Category: immunoglobulin light chain dimer]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 18:36:38 2007''
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Current revision

THREE-DIMENSIONAL STRUCTURE OF AN IMMUNOGLOBULIN LIGHT CHAIN DIMER ACTING AS A LETHAL AMYLOID PRECURSOR

PDB ID 1jvk

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