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1k35

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[[Image:1k35.png|left|200px]]
 
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{{STRUCTURE_1k35| PDB=1k35 | SCENE= }}
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==Crystal Structure of Phosphomannomutase/Phosphoglucomutase from P.aeruginosa==
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<StructureSection load='1k35' size='340' side='right'caption='[[1k35]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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===Crystal Structure of Phosphomannomutase/Phosphoglucomutase from P.aeruginosa===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1k35]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K35 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K35 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_11839312}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k35 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k35 OCA], [https://pdbe.org/1k35 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k35 RCSB], [https://www.ebi.ac.uk/pdbsum/1k35 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k35 ProSAT]</span></td></tr>
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[[1k35]] is a 1 chain structure of [[Phosphomannomutase]] with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K35 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ALGC_PSEAE ALGC_PSEAE] The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to its phosphoglucomutase activity. Essential for rhamnolipid production, an exoproduct correlated with pathogenicity, and for biofilm production.<ref>PMID:7515870</ref> <ref>PMID:10481091</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k3/1k35_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k35 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[Phosphomannomutase|Phosphomannomutase]]
*[[Phosphomannomutase|Phosphomannomutase]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:011839312</ref><references group="xtra"/>
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__TOC__
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[[Category: Phosphomannomutase]]
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Pseudomonas aeruginosa]]
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[[Category: Beamer, L J.]]
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[[Category: Beamer LJ]]
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[[Category: Regni, C.]]
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[[Category: Regni C]]
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[[Category: Tipton, P A.]]
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[[Category: Tipton PA]]
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[[Category: Alpha/beta protein]]
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[[Category: Enzyme-metal complex]]
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[[Category: Isomerase]]
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[[Category: Phosphoserine]]
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Current revision

Crystal Structure of Phosphomannomutase/Phosphoglucomutase from P.aeruginosa

PDB ID 1k35

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