This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.

1k4r

From Proteopedia

(Difference between revisions)

Jump to: navigation, search

Current revision

Structure of Dengue Virus

1k4r, resolution 24.00Å

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1k4r"

@@ Line 1: / Line 1: @@
-[[Image:1k4r.gif|left|200px]]<br /><applet load="1k4r" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="1k4r, resolution 24.&Aring;" />
-'''Structure of Dengue Virus'''<br />
-==Overview==
+==Structure of Dengue Virus==
-The first structure of a flavivirus has been determined by using a, combination of cryoelectron microscopy and fitting of the known structure, of glycoprotein E into the electron density map. The virus core, within a, lipid bilayer, has a less-ordered structure than the external, icosahedral, scaffold of 90 glycoprotein E dimers. The three E monomers per icosahedral, asymmetric unit do not have quasiequivalent symmetric environments., Difference maps indicate the location of the small membrane protein M, relative to the overlaying scaffold of E dimers. The structure suggests, that flaviviruses, and by analogy also alphaviruses, employ a fusion, mechanism in which the distal beta barrels of domain II of the, glycoprotein E are inserted into the cellular membrane.
+<SX load='1k4r' size='340' side='right' viewer='molstar' caption='[[1k4r]], [[Resolution|resolution]] 24.00&Aring;' scene=''>
+== Structural highlights ==
-==About this Structure==
+<table><tr><td colspan='2'>[[1k4r]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Chimeric_Tick-borne_encephalitis_virus/Dengue_virus_4 Chimeric Tick-borne encephalitis virus/Dengue virus 4]. The July 2008 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Dengue Virus''  by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2008_7 10.2210/rcsb_pdb/mom_2008_7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K4R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K4R FirstGlance]. <br>
-K4R is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Tick-borne_encephalitis_virus Tick-borne encephalitis virus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1K4R OCA].
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 24&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k4r OCA], [https://pdbe.org/1k4r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k4r RCSB], [https://www.ebi.ac.uk/pdbsum/1k4r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k4r ProSAT]</span></td></tr>
-==Reference==
+</table>
-Structure of dengue virus: implications for flavivirus organization, maturation, and fusion., Kuhn RJ, Zhang W, Rossmann MG, Pletnev SV, Corver J, Lenches E, Jones CT, Mukhopadhyay S, Chipman PR, Strauss EG, Baker TS, Strauss JH, Cell. 2002 Mar 8;108(5):717-25. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11893341 11893341]
+== Function ==
-[[Category: Single protein]]
+[https://www.uniprot.org/uniprot/C3V005_9FLAV C3V005_9FLAV]
-[[Category: Tick-borne encephalitis virus]]
+== Evolutionary Conservation ==
-[[Category: Baker, T.S.]]
+[[Image:Consurf_key_small.gif|200px|right]]
-[[Category: Chipman, P.R.]]
+Check<jmol>
-[[Category: Corver, J.]]
+  <jmolCheckbox>
-[[Category: Jones, C.T.]]
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k4/1k4r_consurf.spt"</scriptWhenChecked>
-[[Category: Kuhn, R.J.]]
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-[[Category: Lenches, E.]]
+    <text>to colour the structure by Evolutionary Conservation</text>
-[[Category: Mukhopadhyay, S.]]
+  </jmolCheckbox>
-[[Category: Pletnev, S.V.]]
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k4r ConSurf].
-[[Category: Rossmann, M.G.]]
+<div style="clear:both"></div>
-[[Category: Strauss, E.G.]]
+__TOC__
-[[Category: Strauss, J.H.]]
+</SX>
-[[Category: Zhang, W.]]
+[[Category: Chimeric Tick-borne encephalitis virus/Dengue virus 4]]
-[[Category: dengue virus]]
+[[Category: Dengue Virus]]
-[[Category: flaviviridae]]
+[[Category: Large Structures]]
-[[Category: flavivirus]]
+[[Category: RCSB PDB Molecule of the Month]]
-[[Category: glycoprotein e from tick-borne encephalitis virus]]
+[[Category: Baker TS]]
-[[Category: icosahedral virus]]
+[[Category: Chipman PR]]
+[[Category: Corver J]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 18:51:50 2007''
+[[Category: Jones CT]]
+[[Category: Kuhn RJ]]
+[[Category: Lenches E]]
+[[Category: Mukhopadhyay S]]
+[[Category: Pletnev SV]]
+[[Category: Rossmann MG]]
+[[Category: Strauss EG]]
+[[Category: Strauss JH]]
+[[Category: Zhang W]]

1k4r

From Proteopedia

Current revision

Structure of Dengue Virus

Structural highlights

Function

Evolutionary Conservation

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

Personal tools

Navigation

Search

Toolbox