1k6a

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[[Image:1k6a.gif|left|200px]]
 
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==Structural studies on the mobility in the active site of the Thermoascus aurantiacus xylanase I==
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The line below this paragraph, containing "STRUCTURE_1k6a", creates the "Structure Box" on the page.
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<StructureSection load='1k6a' size='340' side='right'caption='[[1k6a]], [[Resolution|resolution]] 1.14&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1k6a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermoascus_aurantiacus Thermoascus aurantiacus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1fxm 1fxm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K6A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K6A FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.14&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k6a OCA], [https://pdbe.org/1k6a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k6a RCSB], [https://www.ebi.ac.uk/pdbsum/1k6a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k6a ProSAT]</span></td></tr>
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{{STRUCTURE_1k6a| PDB=1k6a | SCENE= }}
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</table>
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== Function ==
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'''Structural studies on the mobility in the active site of the Thermoascus aurantiacus xylanase I'''
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[https://www.uniprot.org/uniprot/XYNA_THEAU XYNA_THEAU]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Overview==
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Check<jmol>
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The substrate specificity of Thermoascus aurantiacus xylanase 10A (TAX) has been investigated both biochemically and structurally. High resolution crystallographic analyses at 291 K and 100 K of TAX complexes with xylobiose show that the ligand is in its alpha anomeric conformation and provide a rationale for specificity on p-nitrophenyl glycosides at the -1 and -2 subsites. Trp 275, which is disordered in uncomplexed structures, is stabilised by its interaction with xylobiose. Two structural subsets in family 10 are identified, which differ by the presence or absence of a short helical stretch in the eighth betaalpha-loop of the TIM barrel, the loop bearing Trp 275. This structural difference is discussed in the context of Trp 275 mobility and xylanase function.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k6/1k6a_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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1K6A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermoascus_aurantiacus Thermoascus aurantiacus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1fxm 1fxm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K6A OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==Reference==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k6a ConSurf].
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Substrate specificity and subsite mobility in T. aurantiacus xylanase 10A., Lo Leggio L, Kalogiannis S, Eckert K, Teixeira SC, Bhat MK, Andrei C, Pickersgill RW, Larsen S, FEBS Lett. 2001 Dec 7;509(2):303-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11741607 11741607]
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<div style="clear:both"></div>
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[[Category: Endo-1,4-beta-xylanase]]
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__TOC__
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[[Category: Single protein]]
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Thermoascus aurantiacus]]
[[Category: Thermoascus aurantiacus]]
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[[Category: Andrei, C.]]
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[[Category: Andrei C]]
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[[Category: Bhat, M K.]]
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[[Category: Bhat MK]]
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[[Category: Eckert, K.]]
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[[Category: Eckert K]]
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[[Category: Kalogiannis, S.]]
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[[Category: Kalogiannis S]]
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[[Category: Larsen, S.]]
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[[Category: Larsen S]]
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[[Category: Leggio, L Lo.]]
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[[Category: Lo Leggio L]]
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[[Category: Pickersgill, R W.]]
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[[Category: Pickersgill RW]]
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[[Category: Teixeira, S C.M.]]
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[[Category: Teixeira SCM]]
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[[Category: Active site mobility]]
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[[Category: Alternate conformation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:21:30 2008''
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Current revision

Structural studies on the mobility in the active site of the Thermoascus aurantiacus xylanase I

PDB ID 1k6a

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