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1kc5

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(New page: 200px<br /> <applet load="1kc5" size="450" color="white" frame="true" align="right" spinBox="true" caption="1kc5, resolution 2.50&Aring;" /> '''CRYSTAL STRUCTURE O...)
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[[Image:1kc5.gif|left|200px]]<br />
 
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<applet load="1kc5" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1kc5, resolution 2.50&Aring;" />
 
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'''CRYSTAL STRUCTURE OF ANTIBODY PC287 IN COMPLEX WITH PS1 PEPTIDE'''<br />
 
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==Overview==
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==CRYSTAL STRUCTURE OF ANTIBODY PC287 IN COMPLEX WITH PS1 PEPTIDE==
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Crystal structures of distinct mAbs that recognize a common epitope of a, peptide Ag have been determined and analyzed in the unbound and bound, forms. These Abs display dissimilar binding site structures in the absence, of the Ag. The dissimilarity is primarily expressed in the conformations, of complementarity-determining region H3, which is responsible for, defining the epitope specificity. Interestingly, however, the three Abs, exhibit similar complementarity-determining region conformations in the Ag, binding site while recognizing the common epitope, indicating that, different pathways of binding are used for Ag recognition. The epitope, also exhibits conformational similarity when bound to each of these Abs, although the peptide Ag was otherwise flexible. The observed, conformational convergence in the epitope and the Ag binding site was, facilitated by the plasticity in the nature of interactions.
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<StructureSection load='1kc5' size='340' side='right'caption='[[1kc5]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1kc5]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepatitis_B_virus_genotype_A1_subtype_adw2_(Isolate_South_Africa/84/2001) Hepatitis B virus genotype A1 subtype adw2 (Isolate South Africa/84/2001)] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KC5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KC5 FirstGlance]. <br>
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1KC5 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1KC5 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kc5 OCA], [https://pdbe.org/1kc5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kc5 RCSB], [https://www.ebi.ac.uk/pdbsum/1kc5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kc5 ProSAT]</span></td></tr>
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==Reference==
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</table>
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Epitope recognition by diverse antibodies suggests conformational convergence in an antibody response., Nair DT, Singh K, Siddiqui Z, Nayak BP, Rao KV, Salunke DM, J Immunol. 2002 Mar 1;168(5):2371-82. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11859128 11859128]
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== Function ==
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[https://www.uniprot.org/uniprot/IGKC_MOUSE IGKC_MOUSE]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kc/1kc5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kc5 ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Protein complex]]
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[[Category: Nair DT]]
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[[Category: Nair, D.T.]]
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[[Category: Nayak BP]]
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[[Category: Nayak, B.P.]]
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[[Category: Rao KV]]
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[[Category: Rao, K.V.]]
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[[Category: Salunke DM]]
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[[Category: Salunke, D.M.]]
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[[Category: Siddiqui Z]]
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[[Category: Siddiqui, Z.]]
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[[Category: Singh K]]
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[[Category: Singh, K.]]
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[[Category: antibody]]
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[[Category: complex (antibody/peptide)]]
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[[Category: peptide antigen]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 18 09:34:35 2007''
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Current revision

CRYSTAL STRUCTURE OF ANTIBODY PC287 IN COMPLEX WITH PS1 PEPTIDE

PDB ID 1kc5

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