This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.

1kiv

From Proteopedia

(Difference between revisions)

Jump to: navigation, search

Current revision

RECOMBINANT KRINGLE IV-10/M66 VARIANT OF HUMAN APOLIPOPROTEIN(A)

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1kiv"

Categories: Homo sapiens | Large Structures | Mochalkin I | Scanu A | Tulinsky A

@@ Line 1: / Line 1: @@
-[[Image:1kiv.gif|left|200px]]<br />
-<applet load="1kiv" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="1kiv, resolution 2.1&Aring;" />
-'''RECOMBINANT KRINGLE IV-10/M66 VARIANT OF HUMAN APOLIPOPROTEIN(A)'''<br />
-==Overview==
+==RECOMBINANT KRINGLE IV-10/M66 VARIANT OF HUMAN APOLIPOPROTEIN(A)==
-The kringle modules of apolipoprotein(a) [apo(a)] of lipoprotein(a), [Lp(a)] are highly homologous with kringle 4 of plasminogen (75-94%) and, like the latter are autonomous structural and functional units. Apo(a), contains 14-37 kringle 4 (KIV) repeats distributed into 10 classes (1-10)., Lp(a) binds lysine-Sepharose via a lysine binding site (LBS) located in, KIV-10 (88% homology with plasminogen K4). However, the W72R substitution, that occurs in rhesus monkeys and occasionally in humans leads to impaired, lysine binding capacity of KIV-10 and Lp(a). The foregoing has been, investigated by determining the structures of KIV-10/M66 (M66 variant) in, its unliganded and ligand [epsilon-aminocaproic acid (EACA)] bound modes, and the structure of recombinant KIV-10/M66R72 (the W72R mutant). ... [[http://ispc.weizmann.ac.il/pmbin/getpm?10026282 (full description)]]
+<StructureSection load='1kiv' size='340' side='right'caption='[[1kiv]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
+== Structural highlights ==
-==About this Structure==
+<table><tr><td colspan='2'>[[1kiv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KIV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KIV FirstGlance]. <br>
-KIV is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1KIV OCA]].
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kiv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kiv OCA], [https://pdbe.org/1kiv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kiv RCSB], [https://www.ebi.ac.uk/pdbsum/1kiv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kiv ProSAT]</span></td></tr>
-==Reference==
+</table>
-Recombinant kringle IV-10 modules of human apolipoprotein(a): structure, ligand binding modes, and biological relevance., Mochalkin I, Cheng B, Klezovitch O, Scanu AM, Tulinsky A, Biochemistry. 1999 Feb 16;38(7):1990-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10026282 10026282]
+== Function ==
+[https://www.uniprot.org/uniprot/APOA_HUMAN APOA_HUMAN] Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330.<ref>PMID:2531657</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ki/1kiv_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kiv ConSurf].
+<div style="clear:both"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Mochalkin, I.]]
+[[Category: Mochalkin I]]
-[[Category: Scanu, A.]]
+[[Category: Scanu A]]
-[[Category: Tulinsky, A.]]
+[[Category: Tulinsky A]]
-[[Category: apolipoprotein(a)]]
-[[Category: kringle]]
-[[Category: lysine binding site]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 18:09:50 2007''

1kiv

From Proteopedia

Current revision

RECOMBINANT KRINGLE IV-10/M66 VARIANT OF HUMAN APOLIPOPROTEIN(A)

Structural highlights

Function

Evolutionary Conservation

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

Personal tools

Navigation

Search

Toolbox