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1kli

From Proteopedia

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[[Image:1kli.png|left|200px]]
 
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{{STRUCTURE_1kli| PDB=1kli | SCENE= }}
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==Cofactor-and substrate-assisted activation of factor VIIa==
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<StructureSection load='1kli' size='340' side='right'caption='[[1kli]], [[Resolution|resolution]] 1.69&Aring;' scene=''>
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===Cofactor-and substrate-assisted activation of factor VIIa===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1kli]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KLI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KLI FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12225752}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.69&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kli FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kli OCA], [https://pdbe.org/1kli PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kli RCSB], [https://www.ebi.ac.uk/pdbsum/1kli PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kli ProSAT]</span></td></tr>
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[[1kli]] is a 2 chain structure of [[Factor VIIa]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KLI OCA].
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/FA7_HUMAN FA7_HUMAN] Defects in F7 are the cause of factor VII deficiency (FA7D) [MIM:[https://omim.org/entry/227500 227500]. A hemorrhagic disease with variable presentation. The clinical picture can be very severe, with the early occurrence of intracerebral hemorrhages or repeated hemarthroses, or, in contrast, moderate with cutaneous-mucosal hemorrhages (epistaxis, menorrhagia) or hemorrhages provoked by a surgical intervention. Finally, numerous subjects are completely asymptomatic despite very low factor VII levels.<ref>PMID:8043443</ref> <ref>PMID:2070047</ref> <ref>PMID:1634227</ref> <ref>PMID:8364544</ref> <ref>PMID:8204879</ref> <ref>PMID:7981691</ref> <ref>PMID:7974346</ref> <ref>PMID:8652821</ref> <ref>PMID:8844208</ref> <ref>PMID:8940045</ref> <ref>PMID:8883260</ref> <ref>PMID:9414278</ref> <ref>PMID:9576180</ref> <ref>PMID:9452082</ref> <ref>PMID:11091194</ref> <ref>PMID:11129332</ref> <ref>PMID:10862079</ref> <ref>PMID:12472587</ref> <ref>PMID:14717781</ref> <ref>PMID:19751712</ref> <ref>PMID:18976247</ref> <ref>PMID:19432927</ref> <ref>PMID:21206266</ref> <ref>PMID:21372693</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/FA7_HUMAN FA7_HUMAN] Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kl/1kli_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kli ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Factor VIIa|Factor VIIa]]
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*[[Factor VIIa 3D structures|Factor VIIa 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:012225752</ref><ref group="xtra">PMID:011676542</ref><references group="xtra"/>
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__TOC__
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[[Category: Coagulation factor VIIa]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arcy, A D.]]
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[[Category: Large Structures]]
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[[Category: Banner, D W.]]
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[[Category: Banner DW]]
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[[Category: Bode, W.]]
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[[Category: Bode W]]
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[[Category: Brandstetter, H.]]
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[[Category: Brandstetter H]]
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[[Category: Hopfner, K P.]]
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[[Category: D'Arcy A]]
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[[Category: Huber, R.]]
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[[Category: Hopfner KP]]
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[[Category: Kopetzki, E.]]
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[[Category: Huber R]]
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[[Category: Kresse, G B.]]
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[[Category: Kopetzki E]]
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[[Category: Sichler, K.]]
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[[Category: Kresse GB]]
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[[Category: Extrinsic coagulation pathway]]
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[[Category: Sichler K]]
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[[Category: Hydrolase]]
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[[Category: Rational drug design]]
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[[Category: Serine protease activation]]
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[[Category: Substrate-assisted catalysis]]
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Current revision

Cofactor-and substrate-assisted activation of factor VIIa

PDB ID 1kli

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