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1koe

From Proteopedia

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(New page: 200px<br /><applet load="1koe" size="450" color="white" frame="true" align="right" spinBox="true" caption="1koe, resolution 1.50&Aring;" /> '''ENDOSTATIN'''<br /> ...)
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[[Image:1koe.gif|left|200px]]<br /><applet load="1koe" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1koe, resolution 1.50&Aring;" />
 
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'''ENDOSTATIN'''<br />
 
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==Overview==
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==ENDOSTATIN==
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A number of extracellular proteins contain cryptic inhibitors of, angiogenesis. Endostatin is a 20 kDa C-terminal proteolytic fragment of, collagen XVIII that potently inhibits endothelial cell proliferation and, angiogenesis. Therapy of experimental cancer with endostatin leads to, tumour dormancy and does not induce resistance. We have expressed, recombinant mouse endostatin and determined its crystal structure at 1.5 A, resolution. The structure reveals a compact fold distantly related to the, C-type lectin carbohydrate recognition domain and the hyaluronan-binding, Link module. The high affinity of endostatin for heparin is explained by, the presence of an extensive basic patch formed by 11 arginine residues., Endostatin may inhibit angiogenesis by binding to the heparan sulphate, proteoglycans involved in growth factor signalling.
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<StructureSection load='1koe' size='340' side='right'caption='[[1koe]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1koe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KOE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KOE FirstGlance]. <br>
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1KOE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1KOE OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1koe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1koe OCA], [https://pdbe.org/1koe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1koe RCSB], [https://www.ebi.ac.uk/pdbsum/1koe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1koe ProSAT]</span></td></tr>
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==Reference==
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</table>
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Crystal structure of the angiogenesis inhibitor endostatin at 1.5 A resolution., Hohenester E, Sasaki T, Olsen BR, Timpl R, EMBO J. 1998 Mar 16;17(6):1656-64. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9501087 9501087]
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== Function ==
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[https://www.uniprot.org/uniprot/COIA1_MOUSE COIA1_MOUSE] Endostatin potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ko/1koe_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1koe ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Hohenester E]]
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[[Category: Hohenester, E.]]
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[[Category: Olsen BR]]
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[[Category: Olsen, B.R.]]
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[[Category: Sasaki T]]
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[[Category: Sasaki, T.]]
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[[Category: Timpl R]]
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[[Category: Timpl, R.]]
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[[Category: angiogenesis inhibitor]]
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[[Category: collagen xviii]]
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[[Category: heparin-binding domain]]
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[[Category: non-collageneous domain]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 19:29:19 2007''
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Current revision

ENDOSTATIN

PDB ID 1koe

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