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1ktj

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(New page: 200px<br /><applet load="1ktj" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ktj, resolution 2.15&Aring;" /> '''X-ray Structure Of D...)
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[[Image:1ktj.gif|left|200px]]<br /><applet load="1ktj" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1ktj, resolution 2.15&Aring;" />
 
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'''X-ray Structure Of Der P 2, The Major House Dust Mite Allergen'''<br />
 
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==Overview==
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==X-ray Structure Of Der P 2, The Major House Dust Mite Allergen==
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The crystal structure of the common house mite (Dermatophagoides sp.) Der, p 2 allergen was solved at 2.15 A resolution using the MAD phasing, technique, and refined to an R-factor of 0.209. The refined atomic model, which reveals an immunoglobulin-like tertiary fold, differs in important, ways from the previously described NMR structure, because the two, beta-sheets are significantly further apart and create an internal cavity, which is occupied by a hydrophobic ligand. This interaction is, structurally reminiscent of the binding of a prenyl group by a regulatory, protein, the Rho guanine nucleotide exchange inhibitor. The crystal, structure suggests that binding of non-polar molecules may be essential to, the physiological function of the Der p 2 protein.
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<StructureSection load='1ktj' size='340' side='right'caption='[[1ktj]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1ktj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dermatophagoides_pteronyssinus Dermatophagoides pteronyssinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KTJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KTJ FirstGlance]. <br>
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1KTJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Dermatophagoides_pteronyssinus Dermatophagoides pteronyssinus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1KTJ OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ktj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ktj OCA], [https://pdbe.org/1ktj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ktj RCSB], [https://www.ebi.ac.uk/pdbsum/1ktj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ktj ProSAT]</span></td></tr>
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==Reference==
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</table>
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The crystal structure of a major dust mite allergen Der p 2, and its biological implications., Derewenda U, Li J, Derewenda Z, Dauter Z, Mueller GA, Rule GS, Benjamin DC, J Mol Biol. 2002 Apr 19;318(1):189-97. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12054778 12054778]
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== Function ==
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[https://www.uniprot.org/uniprot/ALL2_DERPT ALL2_DERPT]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kt/1ktj_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ktj ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Dermatophagoides pteronyssinus]]
[[Category: Dermatophagoides pteronyssinus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Benjamin, D.C.]]
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[[Category: Benjamin DC]]
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[[Category: Dauter, Z.]]
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[[Category: Dauter Z]]
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[[Category: Derewenda, U.]]
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[[Category: Derewenda U]]
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[[Category: Derewenda, Z.]]
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[[Category: Derewenda Z]]
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[[Category: Li, J.]]
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[[Category: Li J]]
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[[Category: Mueller, G.A.]]
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[[Category: Mueller GA]]
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[[Category: Rule, G.S.]]
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[[Category: Rule GS]]
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[[Category: allergen]]
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[[Category: asthma]]
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[[Category: hydrophobic cavity]]
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[[Category: immunoglobulin fold]]
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[[Category: x-ray structure]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 19:51:35 2007''
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Current revision

X-ray Structure Of Der P 2, The Major House Dust Mite Allergen

PDB ID 1ktj

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