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1ktk

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{{Seed}}
 
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[[Image:1ktk.png|left|200px]]
 
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<!--
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==Complex of Streptococcal pyrogenic enterotoxin C (SpeC) with a human T cell receptor beta chain (Vbeta2.1)==
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The line below this paragraph, containing "STRUCTURE_1ktk", creates the "Structure Box" on the page.
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<StructureSection load='1ktk' size='340' side='right'caption='[[1ktk]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ktk]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KTK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KTK FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ktk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ktk OCA], [https://pdbe.org/1ktk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ktk RCSB], [https://www.ebi.ac.uk/pdbsum/1ktk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ktk ProSAT]</span></td></tr>
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{{STRUCTURE_1ktk| PDB=1ktk | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SPEC_STRP8 SPEC_STRP8] Superantigen that acts as a causative agent of the symptoms associated with scarlet fever (PubMed:1500157, PubMed:1987034, PubMed:9253413, PubMed:11163233). Has been associated with streptococcal toxic shock-like disease and may play a role in the early events of rheumatic fever (PubMed:1500157, PubMed:9253413, PubMed:11163233). Superantigens cross-link major histocompatibility complex (MHC) class II and T-cell receptor (TCR) molecules, resulting in an overstimulation of T-cells associated with a massive release of pyrogenic and inflammatory cytokines (PubMed:9253413, PubMed:11163233).<ref>PMID:11163233</ref> <ref>PMID:1500157</ref> <ref>PMID:1987034</ref> <ref>PMID:9253413</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kt/1ktk_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ktk ConSurf].
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<div style="clear:both"></div>
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===Complex of Streptococcal pyrogenic enterotoxin C (SpeC) with a human T cell receptor beta chain (Vbeta2.1)===
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==See Also==
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*[[Exotoxin 3D structures|Exotoxin 3D structures]]
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*[[T-cell receptor 3D structures|T-cell receptor 3D structures]]
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<!--
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== References ==
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The line below this paragraph, {{ABSTRACT_PUBMED_12015151}}, adds the Publication Abstract to the page
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<references/>
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(as it appears on PubMed at http://www.pubmed.gov), where 12015151 is the PubMed ID number.
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__TOC__
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</StructureSection>
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{{ABSTRACT_PUBMED_12015151}}
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==About this Structure==
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1KTK is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KTK OCA].
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==Reference==
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Structures of two streptococcal superantigens bound to TCR beta chains reveal diversity in the architecture of T cell signaling complexes., Sundberg EJ, Li H, Llera AS, McCormick JK, Tormo J, Schlievert PM, Karjalainen K, Mariuzza RA, Structure. 2002 May;10(5):687-99. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12015151 12015151]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
[[Category: Streptococcus pyogenes]]
[[Category: Streptococcus pyogenes]]
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[[Category: Karjalainen, K.]]
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[[Category: Karjalainen K]]
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[[Category: Li, H.]]
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[[Category: Li H]]
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[[Category: Llera, A S.]]
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[[Category: Llera AS]]
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[[Category: Mariuzza, R A.]]
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[[Category: Mariuzza RA]]
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[[Category: McCormick, J K.]]
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[[Category: McCormick JK]]
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[[Category: Schlievert, P M.]]
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[[Category: Schlievert PM]]
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[[Category: Sundberg, E J.]]
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[[Category: Sundberg EJ]]
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[[Category: Tormo, J.]]
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[[Category: Tormo J]]
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[[Category: Immunity]]
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[[Category: Streptococcus]]
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[[Category: T cell receptor beta]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:58:27 2008''
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Current revision

Complex of Streptococcal pyrogenic enterotoxin C (SpeC) with a human T cell receptor beta chain (Vbeta2.1)

PDB ID 1ktk

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