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1kui

From Proteopedia

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{{Seed}}
 
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[[Image:1kui.png|left|200px]]
 
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==Crystal Structure of a Taiwan Habu Venom Metalloproteinase complexed with pEQW.==
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The line below this paragraph, containing "STRUCTURE_1kui", creates the "Structure Box" on the page.
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<StructureSection load='1kui' size='340' side='right'caption='[[1kui]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1kui]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Protobothrops_mucrosquamatus Protobothrops mucrosquamatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KUI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KUI FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
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{{STRUCTURE_1kui| PDB=1kui | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kui OCA], [https://pdbe.org/1kui PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kui RCSB], [https://www.ebi.ac.uk/pdbsum/1kui PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kui ProSAT]</span></td></tr>
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</table>
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===Crystal Structure of a Taiwan Habu Venom Metalloproteinase complexed with pEQW.===
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== Function ==
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[https://www.uniprot.org/uniprot/VM2T3_PROMU VM2T3_PROMU] Snake venom metalloproteinase TM-3: fibrin(ogen)olytic protease which cleaves the Aalpha chain of fibrinogen (FGA) first followed by the Bbeta chain (FGB) and shows relatively low activity on the gamma chain (FGG).<ref>PMID:8068721</ref> <ref>PMID:8193588</ref> Disintegrin trimucrin: inhibits platelet aggregation induced by ADP, thrombin, platelet-activating factor and collagen. Acts by inhibiting fibrinogen interaction with platelet receptors GPIIb/GPIIIa (ITGA2B/ITGB3).<ref>PMID:8068721</ref> <ref>PMID:8193588</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 12071970 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ku/1kui_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_12071970}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1KUI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Protobothrops_mucrosquamatus Protobothrops mucrosquamatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KUI OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kui ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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Determinants of the inhibition of a Taiwan habu venom metalloproteinase by its endogenous inhibitors revealed by X-ray crystallography and synthetic inhibitor analogues., Huang KF, Chiou SH, Ko TP, Wang AH, Eur J Biochem. 2002 Jun;269(12):3047-56. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12071970 12071970]
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<references/>
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[[Category: Atrolysin E]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Protobothrops mucrosquamatus]]
[[Category: Protobothrops mucrosquamatus]]
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[[Category: Single protein]]
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[[Category: Chiou SH]]
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[[Category: Chiou, S H.]]
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[[Category: Huang KF]]
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[[Category: Huang, K F.]]
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[[Category: Ko TP]]
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[[Category: Ko, T P.]]
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[[Category: Wang AHJ]]
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[[Category: Wang, A H.J.]]
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[[Category: Alpha/beta protein]]
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[[Category: Retro-binding manner]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:01:37 2008''
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Current revision

Crystal Structure of a Taiwan Habu Venom Metalloproteinase complexed with pEQW.

PDB ID 1kui

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