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1kvo

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HUMAN PHOSPHOLIPASE A2 COMPLEXED WITH A HIGHLY POTENT SUBSTRATE ANOLOGUE

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Retrieved from "http://52.214.119.220/wiki/index.php/1kvo"

Categories: Homo sapiens | Large Structures | Abdel-Meguid SS | Cha S-S | Oh B-H

@@ Line 1: / Line 1: @@
-[[Image:1kvo.gif|left|200px]]
- {{Structure
+==HUMAN PHOSPHOLIPASE A2 COMPLEXED WITH A HIGHLY POTENT SUBSTRATE ANOLOGUE==
-|PDB= 1kvo |SIZE=350|CAPTION= <scene name='initialview01'>1kvo</scene>, resolution 2.0&Aring;
+<StructureSection load='1kvo' size='340' side='right'caption='[[1kvo]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=OAP:4-(S)-[(1-OXO-7-PHENYLHEPTYL)AMINO]-5-[4-(PHENYLMETHYL)PHENYLTHIO]PENTANOIC+ACID'>OAP</scene>
+<table><tr><td colspan='2'>[[1kvo]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KVO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KVO FirstGlance]. <br>
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-|GENE=
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=OAP:4-(S)-[(1-OXO-7-PHENYLHEPTYL)AMINO]-5-[4-(PHENYLMETHYL)PHENYLTHIO]PENTANOIC+ACID'>OAP</scene></td></tr>
-|DOMAIN=
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kvo OCA], [https://pdbe.org/1kvo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kvo RCSB], [https://www.ebi.ac.uk/pdbsum/1kvo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kvo ProSAT]</span></td></tr>
-|RELATEDENTRY=
+</table>
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kvo OCA], [http://www.ebi.ac.uk/pdbsum/1kvo PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1kvo RCSB]</span>
+== Function ==
-}}
+[https://www.uniprot.org/uniprot/PA2GA_HUMAN PA2GA_HUMAN] Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kv/1kvo_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kvo ConSurf].
+<div style="clear:both"></div>
-'''HUMAN PHOSPHOLIPASE A2 COMPLEXED WITH A HIGHLY POTENT SUBSTRATE ANOLOGUE'''
+==See Also==
+*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
+__TOC__
-==About this Structure==
+</StructureSection>
-KVO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KVO OCA].
-==Reference==
-High-resolution X-ray crystallography reveals precise binding interactions between human nonpancreatic secreted phospholipase A2 and a highly potent inhibitor (FPL67047XX)., Cha SS, Lee D, Adams J, Kurdyla JT, Jones CS, Marshall LA, Bolognese B, Abdel-Meguid SS, Oh BH, J Med Chem. 1996 Sep 27;39(20):3878-81. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8831753 8831753]
 [[Category: Homo sapiens]]
-[[Category: Phospholipase A(2)]]
+[[Category: Large Structures]]
-[[Category: Single protein]]
+[[Category: Abdel-Meguid SS]]
-[[Category: Abdel-Meguid, S S.]]
+[[Category: Cha S-S]]
-[[Category: Cha, S S.]]
+[[Category: Oh B-H]]
-[[Category: Oh, B H.]]
-[[Category: calcium]]
-[[Category: hydrolase]]
-[[Category: lipid degradation]]
-[[Category: membrane]]
-[[Category: signal]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:54:16 2008''

1kvo

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HUMAN PHOSPHOLIPASE A2 COMPLEXED WITH A HIGHLY POTENT SUBSTRATE ANOLOGUE

Structural highlights

Function

Evolutionary Conservation

See Also

Contents

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