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1kww

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{{Seed}}
 
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[[Image:1kww.png|left|200px]]
 
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<!--
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==Rat mannose protein A complexed with a-Me-Fuc.==
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The line below this paragraph, containing "STRUCTURE_1kww", creates the "Structure Box" on the page.
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<StructureSection load='1kww' size='340' side='right'caption='[[1kww]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1kww]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KWW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KWW FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MFU:ALPHA-L-METHYL-FUCOSE'>MFU</scene></td></tr>
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{{STRUCTURE_1kww| PDB=1kww | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kww OCA], [https://pdbe.org/1kww PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kww RCSB], [https://www.ebi.ac.uk/pdbsum/1kww PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kww ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MBL1_RAT MBL1_RAT] Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kw/1kww_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kww ConSurf].
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<div style="clear:both"></div>
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===Rat mannose protein A complexed with a-Me-Fuc.===
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==See Also==
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*[[Mannose-binding protein|Mannose-binding protein]]
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__TOC__
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<!--
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_11850428}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 11850428 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11850428}}
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==About this Structure==
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1KWW is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KWW OCA].
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==Reference==
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<ref group="xtra">PMID:11850428</ref><references group="xtra"/>
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Clark, D A.]]
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[[Category: Clark DA]]
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[[Category: Drickamer, K.]]
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[[Category: Drickamer K]]
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[[Category: Feinberg, H.]]
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[[Category: Feinberg H]]
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[[Category: Kolatkar, A R.]]
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[[Category: Kolatkar AR]]
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[[Category: Ng, K K.]]
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[[Category: Ng KK]]
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[[Category: Park-Snyder, S.]]
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[[Category: Park-Snyder S]]
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[[Category: Weis, W I.]]
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[[Category: Weis WI]]
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[[Category: C-type lectin]]
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[[Category: Calcium-binding protein]]
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[[Category: Lectin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 15:05:27 2009''
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Current revision

Rat mannose protein A complexed with a-Me-Fuc.

PDB ID 1kww

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