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1kx9

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[[Image:1kx9.gif|left|200px]]
 
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{{Structure
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==ANTENNAL CHEMOSENSORY PROTEIN A6 FROM THE MOTH MAMESTRA BRASSICAE==
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|PDB= 1kx9 |SIZE=350|CAPTION= <scene name='initialview01'>1kx9</scene>, resolution 1.65&Aring;
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<StructureSection load='1kx9' size='340' side='right'caption='[[1kx9]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>
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<table><tr><td colspan='2'>[[1kx9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mamestra_brassicae Mamestra brassicae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KX9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KX9 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kx9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kx9 OCA], [https://pdbe.org/1kx9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kx9 RCSB], [https://www.ebi.ac.uk/pdbsum/1kx9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kx9 ProSAT]</span></td></tr>
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|RELATEDENTRY=[[1kx8|1KX8]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kx9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kx9 OCA], [http://www.ebi.ac.uk/pdbsum/1kx9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1kx9 RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/Q9NG96_MAMBR Q9NG96_MAMBR]
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== Evolutionary Conservation ==
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'''ANTENNAL CHEMOSENSORY PROTEIN A6 FROM THE MOTH MAMESTRA BRASSICAE'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==Overview==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kx/1kx9_consurf.spt"</scriptWhenChecked>
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Chemosensory proteins (CSPs) are believed to be involved in chemical communication and perception. Such proteins, of M(r) 13,000, have been isolated from several sensory organs of a wide range of insect species. Several CSPs have been identified in the antennae and proboscis of the moth Mamestra brassicae. One of them, CSPMbraA6, a 112-amino acid antennal protein, has been expressed in large quantities and is soluble in the Escherichia coli periplasm. X-ray structure determination has been performed in parallel with ligand binding assays using tryptophan fluorescence quenching. The protein has overall dimensions of 25 x 30 x 32 A and exhibits a novel type of alpha-helical fold with six helices connected by alpha-alpha loops. A narrow channel extends within the protein hydrophobic core. Fluorescence quenching with brominated alkyl alcohols or fatty acids and modeling studies indicates that CSPMbraA6 is able to bind such compounds with C12-18 alkyl chains. These ubiquitous proteins might have the role of extracting hydrophobic linear compounds (pheromones, odors, or fatty acids) dispersed in the phospholipid membrane and transporting them to their receptor.
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1KX9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mamestra_brassicae Mamestra brassicae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KX9 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kx9 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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X-ray structure and ligand binding study of a moth chemosensory protein., Lartigue A, Campanacci V, Roussel A, Larsson AM, Jones TA, Tegoni M, Cambillau C, J Biol Chem. 2002 Aug 30;277(35):32094-8. Epub 2002 Jun 14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12068017 12068017]
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mamestra brassicae]]
[[Category: Mamestra brassicae]]
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[[Category: Single protein]]
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[[Category: Cambillau C]]
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[[Category: Cambillau, C.]]
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[[Category: Campanacci V]]
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[[Category: Campanacci, V.]]
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[[Category: Jones TA]]
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[[Category: Jones, T A.]]
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[[Category: Larsson AM]]
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[[Category: Larsson, A M.]]
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[[Category: Lartigue A]]
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[[Category: Lartigue, A.]]
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[[Category: Roussel A]]
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[[Category: Roussel, A.]]
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[[Category: Tegoni M]]
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[[Category: Tegoni, M.]]
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[[Category: all helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:54:57 2008''
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Current revision

ANTENNAL CHEMOSENSORY PROTEIN A6 FROM THE MOTH MAMESTRA BRASSICAE

PDB ID 1kx9

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