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1kxi
From Proteopedia
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| - | [[Image:1kxi.png|left|200px]] | ||
| - | + | ==STRUCTURE OF CYTOTOXIN HOMOLOG PRECURSOR== | |
| - | + | <StructureSection load='1kxi' size='340' side='right'caption='[[1kxi]], [[Resolution|resolution]] 2.19Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1kxi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KXI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KXI FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.19Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kxi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kxi OCA], [https://pdbe.org/1kxi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kxi RCSB], [https://www.ebi.ac.uk/pdbsum/1kxi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kxi ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | [[1kxi]] is a 2 chain structure | + | == Function == |
| + | [https://www.uniprot.org/uniprot/3SOF5_NAJAT 3SOF5_NAJAT] Non-cytotoxic protein that does not show lytic and hemolytic activities, but can induce aggregation and fusion of sphingomyelin vesicles (PubMed:8182052). It binds to integrin alpha-V/beta-3 (ITGAV/ITGB3) with high affinity, and it inhibits osteoclast differentiation and bone resorption in mice, probably due to binding to integrin alpha-V/beta-3 (PubMed:16407244).<ref>PMID:14743531</ref> <ref>PMID:16407244</ref> <ref>PMID:8182052</ref> <ref>PMID:8703922</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kx/1kxi_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kxi ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Cardiotoxin|Cardiotoxin]] | + | *[[Cardiotoxin 3D structures|Cardiotoxin 3D structures]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Naja atra]] | [[Category: Naja atra]] | ||
| - | [[Category: Chiang | + | [[Category: Chiang C-M]] |
| - | [[Category: Hsiao | + | [[Category: Hsiao C-D]] |
| - | [[Category: Hsin | + | [[Category: Hsin A-Y]] |
| - | [[Category: Sun | + | [[Category: Sun Y-J]] |
| - | [[Category: Wu | + | [[Category: Wu W-G]] |
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Current revision
STRUCTURE OF CYTOTOXIN HOMOLOG PRECURSOR
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Categories: Large Structures | Naja atra | Chiang C-M | Hsiao C-D | Hsin A-Y | Sun Y-J | Wu W-G
