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1kyn

From Proteopedia

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[[Image:1kyn.png|left|200px]]
 
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{{STRUCTURE_1kyn| PDB=1kyn | SCENE= }}
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==Cathepsin-G==
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<StructureSection load='1kyn' size='340' side='right'caption='[[1kyn]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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===Cathepsin-G===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1kyn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KYN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KYN FirstGlance]. <br>
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{{ABSTRACT_PUBMED_11942800}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KTP:(2-NAPHTHALEN-2-YL-1-NAPHTHALEN-1-YL-2-OXO-ETHYL)-PHOSPHONIC+ACID'>KTP</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kyn OCA], [https://pdbe.org/1kyn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kyn RCSB], [https://www.ebi.ac.uk/pdbsum/1kyn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kyn ProSAT]</span></td></tr>
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[[1kyn]] is a 2 chain structure of [[Cathepsin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KYN OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CATG_HUMAN CATG_HUMAN] Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride.<ref>PMID:8194606</ref> <ref>PMID:1861080</ref> <ref>PMID:1937776</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ky/1kyn_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kyn ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Cathepsin|Cathepsin]]
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*[[Cathepsin 3D structures|Cathepsin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:011942800</ref><references group="xtra"/>
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__TOC__
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[[Category: Cathepsin G]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Almond, H R.]]
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[[Category: Large Structures]]
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[[Category: Andrade-Gordon, P.]]
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[[Category: Almond Jr HR]]
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[[Category: Chattopadhyay, D.]]
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[[Category: Andrade-Gordon P]]
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[[Category: Corcoran, T W.]]
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[[Category: Chattopadhyay D]]
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[[Category: Garavilla, L De.]]
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[[Category: Corcoran TW]]
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[[Category: Greco, M N.]]
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[[Category: De Garavilla L]]
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[[Category: Hawkins, M J.]]
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[[Category: Greco MN]]
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[[Category: Kauffman, J A.]]
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[[Category: Hawkins MJ]]
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[[Category: Maryanoff, B E.]]
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[[Category: Kauffman JA]]
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[[Category: Powell, E T.]]
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[[Category: Maryanoff BE]]
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[[Category: Recacha, R.]]
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[[Category: Powell ET]]
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[[Category: Hydrolase]]
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[[Category: Recacha R]]
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[[Category: Serine protease]]
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Current revision

Cathepsin-G

PDB ID 1kyn

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