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1kz7

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{{Seed}}
 
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[[Image:1kz7.png|left|200px]]
 
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==Crystal Structure of the DH/PH Fragment of Murine Dbs in Complex with the Placental Isoform of Human Cdc42==
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The line below this paragraph, containing "STRUCTURE_1kz7", creates the "Structure Box" on the page.
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<StructureSection load='1kz7' size='340' side='right'caption='[[1kz7]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1kz7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KZ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KZ7 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_1kz7| PDB=1kz7 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kz7 OCA], [https://pdbe.org/1kz7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kz7 RCSB], [https://www.ebi.ac.uk/pdbsum/1kz7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kz7 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CDC42_HUMAN CDC42_HUMAN] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.<ref>PMID:14978216</ref> <ref>PMID:15642749</ref> <ref>PMID:17038317</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kz/1kz7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kz7 ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of the DH/PH Fragment of Murine Dbs in Complex with the Placental Isoform of Human Cdc42===
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==See Also==
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*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 11889037 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_11889037}}
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==About this Structure==
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1KZ7 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KZ7 OCA].
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==Reference==
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A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange., Rossman KL, Worthylake DK, Snyder JT, Siderovski DP, Campbell SL, Sondek J, EMBO J. 2002 Mar 15;21(6):1315-26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11889037 11889037]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Protein complex]]
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[[Category: Campbell SL]]
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[[Category: Campbell, S L.]]
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[[Category: Rossman KL]]
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[[Category: Rossman, K L.]]
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[[Category: Siderovski DP]]
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[[Category: Siderovski, D P.]]
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[[Category: Snyder JT]]
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[[Category: Snyder, J T.]]
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[[Category: Sondek J]]
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[[Category: Sondek, J.]]
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[[Category: Worthylake DK]]
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[[Category: Worthylake, D K.]]
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[[Category: Small g-protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:20:30 2008''
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Current revision

Crystal Structure of the DH/PH Fragment of Murine Dbs in Complex with the Placental Isoform of Human Cdc42

PDB ID 1kz7

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