This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1l3h

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:05, 3 April 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1l3h.png|left|200px]]
 
-
<!--
+
==NMR structure of P41icf, a potent inhibitor of human cathepsin L==
-
The line below this paragraph, containing "STRUCTURE_1l3h", creates the "Structure Box" on the page.
+
<StructureSection load='1l3h' size='340' side='right'caption='[[1l3h]]' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1l3h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L3H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L3H FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l3h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l3h OCA], [https://pdbe.org/1l3h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l3h RCSB], [https://www.ebi.ac.uk/pdbsum/1l3h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l3h ProSAT]</span></td></tr>
-
{{STRUCTURE_1l3h| PDB=1l3h | SCENE= }}
+
</table>
-
 
+
== Disease ==
-
===NMR structure of P41icf, a potent inhibitor of human cathepsin L===
+
[https://www.uniprot.org/uniprot/HG2A_HUMAN HG2A_HUMAN] Note=A chromosomal aberration involving CD74 is found in a non-small cell lung tumor. Results in the formation of a CD74-ROS1 chimeric protein.<ref>PMID:12661006</ref>
-
 
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/HG2A_HUMAN HG2A_HUMAN] Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.
-
<!--
+
== Evolutionary Conservation ==
-
The line below this paragraph, {{ABSTRACT_PUBMED_12568610}}, adds the Publication Abstract to the page
+
[[Image:Consurf_key_small.gif|200px|right]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 12568610 is the PubMed ID number.
+
Check<jmol>
-
-->
+
<jmolCheckbox>
-
{{ABSTRACT_PUBMED_12568610}}
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l3/1l3h_consurf.spt"</scriptWhenChecked>
-
 
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
==About this Structure==
+
<text>to colour the structure by Evolutionary Conservation</text>
-
1L3H is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L3H OCA].
+
</jmolCheckbox>
-
 
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l3h ConSurf].
-
==Reference==
+
<div style="clear:both"></div>
-
<ref group="xtra">PMID:12568610</ref><references group="xtra"/>
+
== References ==
-
[[Category: Barthe, P.]]
+
<references/>
-
[[Category: Chiva, C.]]
+
__TOC__
-
[[Category: Codina, A.]]
+
</StructureSection>
-
[[Category: Giralt, E.]]
+
[[Category: Homo sapiens]]
-
[[Category: Alpha helix]]
+
[[Category: Large Structures]]
-
[[Category: Beta sheet]]
+
[[Category: Barthe P]]
-
[[Category: Disulfide bond]]
+
[[Category: Chiva C]]
-
 
+
[[Category: Codina A]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 11:49:53 2009''
+
[[Category: Giralt E]]

Current revision

NMR structure of P41icf, a potent inhibitor of human cathepsin L

PDB ID 1l3h

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1l3h"
Personal tools