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1l8r

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[[Image:1l8r.jpg|left|200px]]
 
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==Structure of the Retinal Determination Protein Dachshund Reveals a DNA-Binding Motif==
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The line below this paragraph, containing "STRUCTURE_1l8r", creates the "Structure Box" on the page.
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<StructureSection load='1l8r' size='340' side='right'caption='[[1l8r]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1l8r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L8R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L8R FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_1l8r| PDB=1l8r | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l8r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l8r OCA], [https://pdbe.org/1l8r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l8r RCSB], [https://www.ebi.ac.uk/pdbsum/1l8r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l8r ProSAT]</span></td></tr>
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</table>
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'''Structure of the Retinal Determination Protein Dachshund Reveals a DNA-Binding Motif'''
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== Function ==
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[https://www.uniprot.org/uniprot/DACH1_HUMAN DACH1_HUMAN] Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity).<ref>PMID:14525983</ref>
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== Evolutionary Conservation ==
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==Overview==
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[[Image:Consurf_key_small.gif|200px|right]]
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The Dachshund proteins are essential components of a regulatory network controlling cell fate determination. They have been implicated in eye, limb, brain, and muscle development. These proteins cannot be assigned to any recognizable structural or functional class based on amino acid sequence analysis. The 1.65 A crystal structure of the most conserved domain of human DACHSHUND is reported here. The protein forms an alpha/beta structure containing a DNA binding motif similar to that found in the winged helix/forkhead subgroup of the helix-turn-helix family. This unexpected finding alters the previously proposed molecular models for the role of Dachshund in the eye determination pathway. Furthermore, it provides a rational framework for future mechanistic analyses of the Dachshund proteins in several developmental contexts.
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l8/1l8r_consurf.spt"</scriptWhenChecked>
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1L8R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L8R OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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Structure of the retinal determination protein Dachshund reveals a DNA binding motif., Kim SS, Zhang RG, Braunstein SE, Joachimiak A, Cvekl A, Hegde RS, Structure. 2002 Jun;10(6):787-95. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12057194 12057194]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l8r ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Braunstein, S E.]]
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[[Category: Braunstein SE]]
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[[Category: Cvekl, A.]]
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[[Category: Cvekl A]]
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[[Category: Hegde, R S.]]
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[[Category: Hegde RS]]
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[[Category: Joachimiak, A.]]
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[[Category: Joachimiak A]]
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[[Category: Kim, S S.]]
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[[Category: Kim SS]]
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[[Category: Zhang, R.]]
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[[Category: Zhang R]]
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[[Category: Winged-helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:40:21 2008''
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Current revision

Structure of the Retinal Determination Protein Dachshund Reveals a DNA-Binding Motif

PDB ID 1l8r

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