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1l8r

From Proteopedia

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{{Seed}}
 
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[[Image:1l8r.png|left|200px]]
 
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==Structure of the Retinal Determination Protein Dachshund Reveals a DNA-Binding Motif==
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The line below this paragraph, containing "STRUCTURE_1l8r", creates the "Structure Box" on the page.
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<StructureSection load='1l8r' size='340' side='right'caption='[[1l8r]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1l8r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L8R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L8R FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_1l8r| PDB=1l8r | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l8r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l8r OCA], [https://pdbe.org/1l8r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l8r RCSB], [https://www.ebi.ac.uk/pdbsum/1l8r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l8r ProSAT]</span></td></tr>
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</table>
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===Structure of the Retinal Determination Protein Dachshund Reveals a DNA-Binding Motif===
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== Function ==
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[https://www.uniprot.org/uniprot/DACH1_HUMAN DACH1_HUMAN] Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity).<ref>PMID:14525983</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_12057194}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 12057194 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l8/1l8r_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_12057194}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1L8R is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L8R OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l8r ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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<ref group="xtra">PMID:12057194</ref><references group="xtra"/>
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Braunstein, S E.]]
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[[Category: Large Structures]]
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[[Category: Cvekl, A.]]
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[[Category: Braunstein SE]]
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[[Category: Hegde, R S.]]
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[[Category: Cvekl A]]
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[[Category: Joachimiak, A.]]
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[[Category: Hegde RS]]
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[[Category: Kim, S S.]]
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[[Category: Joachimiak A]]
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[[Category: Zhang, R.]]
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[[Category: Kim SS]]
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[[Category: Winged-helix]]
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[[Category: Zhang R]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 18:56:28 2009''
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Current revision

Structure of the Retinal Determination Protein Dachshund Reveals a DNA-Binding Motif

PDB ID 1l8r

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