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1lit

From Proteopedia

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[[Image:1lit.gif|left|200px]]
 
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{{Structure
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==HUMAN LITHOSTATHINE==
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|PDB= 1lit |SIZE=350|CAPTION= <scene name='initialview01'>1lit</scene>, resolution 1.55&Aring;
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<StructureSection load='1lit' size='340' side='right'caption='[[1lit]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1lit]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LIT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LIT FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lit OCA], [https://pdbe.org/1lit PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lit RCSB], [https://www.ebi.ac.uk/pdbsum/1lit PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lit ProSAT]</span></td></tr>
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}}
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</table>
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== Function ==
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'''HUMAN LITHOSTATHINE'''
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[https://www.uniprot.org/uniprot/REG1A_HUMAN REG1A_HUMAN] Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Overview==
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Check<jmol>
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Human lithostathine (HLIT) is a pancreatic glycoprotein which inhibits the growth and nucleation of calcium carbonate crystals. The crystal structure of the monomeric 17 kDa HLIT, determined to a resolution of 1.55 angstroms, was refined to a crystallographic R-factor of 18.6%. Structural comparison with the carbohydrate-recognition domains of rat mannose-binding protein and E-selectin indicates that the C-terminal domain of HLIT shares a common architecture with the C-type lectins. Nevertheless, HLIT does not bind carbohydrate nor does it contain the characteristic calcium-binding sites of the C-type lectins. In consequence, HLIT represents the first structurally characterized member of this superfamily which is not a lectin. Analysis of the charge distribution and calculation of its dipole moment reveal that HLIT is a strongly polarized molecule. Eight acidic residues which are separated by regular 6 angstrom spacings form a unique and continuous patch on the molecular surface. This arrangement coincides with the distribution of calcium ions on certain planes of the calcium carbonate crystal; the dipole moment of HLIT may play a role in orienting the protein on the crystal surface prior to the more specific interactions of the acidic residues.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/li/1lit_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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1LIT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LIT OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==Reference==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lit ConSurf].
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Crystal structure of human lithostathine, the pancreatic inhibitor of stone formation., Bertrand JA, Pignol D, Bernard JP, Verdier JM, Dagorn JC, Fontecilla-Camps JC, EMBO J. 1996 Jun 3;15(11):2678-84. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8654365 8654365]
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Bernard, J P.]]
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[[Category: Bernard J-P]]
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[[Category: Bertrand, J A.]]
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[[Category: Bertrand JA]]
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[[Category: Dagorn, J C.]]
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[[Category: Dagorn J-C]]
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[[Category: Fontacilla-Camps, J C.]]
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[[Category: Fontacilla-Camps JC]]
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[[Category: Pignol, D.]]
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[[Category: Pignol D]]
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[[Category: Verdier, J M.]]
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[[Category: Verdier J-M]]
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[[Category: lectin]]
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[[Category: pancreatic stone inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:31:23 2008''
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Current revision

HUMAN LITHOSTATHINE

PDB ID 1lit

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