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1lit

From Proteopedia

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HUMAN LITHOSTATHINE

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OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1lit"

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-[[Image:1lit.gif|left|200px]]
- {{Structure
+==HUMAN LITHOSTATHINE==
-|PDB= 1lit |SIZE=350|CAPTION= <scene name='initialview01'>1lit</scene>, resolution 1.55&Aring;
+<StructureSection load='1lit' size='340' side='right'caption='[[1lit]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND=
+<table><tr><td colspan='2'>[[1lit]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LIT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LIT FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
-|GENE=
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lit OCA], [https://pdbe.org/1lit PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lit RCSB], [https://www.ebi.ac.uk/pdbsum/1lit PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lit ProSAT]</span></td></tr>
-|DOMAIN=
+</table>
-|RELATEDENTRY=
+== Function ==
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lit OCA], [http://www.ebi.ac.uk/pdbsum/1lit PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1lit RCSB]</span>
+[https://www.uniprot.org/uniprot/REG1A_HUMAN REG1A_HUMAN] Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration.
-}}
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
-'''HUMAN LITHOSTATHINE'''
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/li/1lit_consurf.spt"</scriptWhenChecked>
-==Overview==
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-Human lithostathine (HLIT) is a pancreatic glycoprotein which inhibits the growth and nucleation of calcium carbonate crystals. The crystal structure of the monomeric 17 kDa HLIT, determined to a resolution of 1.55 angstroms, was refined to a crystallographic R-factor of 18.6%. Structural comparison with the carbohydrate-recognition domains of rat mannose-binding protein and E-selectin indicates that the C-terminal domain of HLIT shares a common architecture with the C-type lectins. Nevertheless, HLIT does not bind carbohydrate nor does it contain the characteristic calcium-binding sites of the C-type lectins. In consequence, HLIT represents the first structurally characterized member of this superfamily which is not a lectin. Analysis of the charge distribution and calculation of its dipole moment reveal that HLIT is a strongly polarized molecule. Eight acidic residues which are separated by regular 6 angstrom spacings form a unique and continuous patch on the molecular surface. This arrangement coincides with the distribution of calcium ions on certain planes of the calcium carbonate crystal; the dipole moment of HLIT may play a role in orienting the protein on the crystal surface prior to the more specific interactions of the acidic residues.
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
-==About this Structure==
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lit ConSurf].
-LIT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LIT OCA].
+<div style="clear:both"></div>
+__TOC__
-==Reference==
+</StructureSection>
-Crystal structure of human lithostathine, the pancreatic inhibitor of stone formation., Bertrand JA, Pignol D, Bernard JP, Verdier JM, Dagorn JC, Fontecilla-Camps JC, EMBO J. 1996 Jun 3;15(11):2678-84. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8654365 8654365]
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Bernard, J P.]]
+[[Category: Bernard J-P]]
-[[Category: Bertrand, J A.]]
+[[Category: Bertrand JA]]
-[[Category: Dagorn, J C.]]
+[[Category: Dagorn J-C]]
-[[Category: Fontacilla-Camps, J C.]]
+[[Category: Fontacilla-Camps JC]]
-[[Category: Pignol, D.]]
+[[Category: Pignol D]]
-[[Category: Verdier, J M.]]
+[[Category: Verdier J-M]]
-[[Category: lectin]]
-[[Category: pancreatic stone inhibitor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:03:19 2008''

1lit

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HUMAN LITHOSTATHINE

Structural highlights

Function

Evolutionary Conservation

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