This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


Virus protease 3D structures

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:26, 3 April 2024) (edit) (undo)
 
(23 intermediate revisions not shown.)
Line 70: Line 70:
*'''Orf 17'''
*'''Orf 17'''
-
**[[3njq]] – hOrf 17 - human herpes virus 8
+
**[[3njq]] – hOrf 17 - human gammaherpesvirus 8<br />
 +
**[[3njq]], [[5ur3]], [[5ute]], [[5utn]], [[5uv3]], [[5uvp]], [[5v5d]], [[5v5e]] – hOrf 17 + inhibitor<br />
*'''Dengue virus protease'''
*'''Dengue virus protease'''
-
**[[3u1i]] – DvNs2b + peptide – Dengue virus<br />
+
**[[3lkw]] – Dv12Ns2b/Dv12Ns3 (mutant) - Dengue virus 1<br />
-
**[[3u1j]] – DvNs2b + BPTI<br />
+
**[[4m9f]], [[4m9i]], [[4m9k]], [[4m9m]] - Dv2Ns2b/Dv2Ns3 (mutant) - Dengue virus 2<br />
-
**[[2fom]] - DvNs2b/DvNs3<br />
+
**[[6mo0]], [[6mo1]], [[6mo2]] – Dv2Ns2b + inhibitor<br />
-
**[[4m9f]], [[4m9i]], [[4m9k]], [[4m9m]], [[3lkw]] - DvNs2b/DvNs3 (mutant)<br />
+
**[[4m9t]] - Dv2Ns2b/Dv2Ns3 (mutant) + inhibitor<br />
-
**[[6mo0]], [[6mo1]], [[6mo2]] - DvNs2b residues 1394-1440 + inhibitor<br />
+
**[[2m9p]], [[2m9q]] – Dv2Ns2b/Dv2Ns3 + inhibitor - NMR<br />
-
**[[4m9t]] - DvNs2b/DvNs3 (mutant) + inhibitor<br />
+
**[[3u1i]] – Dv3Ns2b + peptide – Dengue virus 3<br />
-
**[[2jlq]] – DvNs3 residues 1646-2092 <br />
+
**[[3u1j]] – Dv3Ns2b/Dv3Ns3 + inhibitor<br />
-
**[[2jlv]] – DvNs3 residues 1646-2092 + AMPPNP + RNA<br />
+
**[[2jlq]], [[5yvu]], [[5yvv]], [[5yvw]], [[5yvy]] – Dv4Ns3 – Dengue virus 4<br />
-
**[[2jlr]] – DvNs3 residues 1646-2092 + AMPPNP<br />
+
**[[5xc7]] – Dv4Ns3 (mutant)<br />
-
**[[2jls]] – DvNs3 residues 1646-2092 + ADP<br />
+
**[[5yvj]] – Dv4Ns2b/Dv4Ns3 <br />
-
**[[2jlx]], [[2jly]], [[2jlz]] – DvNs3 residues 1646-2092 + ADP + RNA<br />
+
**[[2whx]] – Dv4Ns2b/Dv4Ns3 + ADP<br />
-
**[[2jlu]], [[2jlw]] – DvNs3 residues 1646-2092 + RNA<br />
+
**[[2jlr]] – Dv4Ns3 + AMPPNP <br />
-
**[[2vbc]], [[2whx]], [[2wzq]] – DvNs3 residues 1475-2092 + peptide inhibitor<br />
+
**[[2jlu]], [[2jlw]] – Dv4Ns3 + RNA<br />
-
**[[2m9p]], [[2m9q]] – DvNs3 residues 1475-1648 + peptide inhibitor - NMR<br />
+
**[[2jls]], [[2jlx]], [[2jly]], [[2jlz]] – Dv4Ns3 + ADP + RNA<br />
-
**[[6izy]] – DvNs5 RNA polymerase domain residues 2742-3387 <br />
+
**[[2jlv]] – Dv4Ns3 + AMPPNP + RNA<br />
-
**[[6izx]] – DvNs5 RNA polymerase domain residues 2742-3387 + inhibitor<br />
+
**[[5yw1]] – Dv4Ns3 + BPTI <br />
 +
**[[2vbc]], [[2wzq]] – Dv4Ns3 residues 1475-2092 + peptide inhibitor<br />
*'''Herpes simplex virus protease'''
*'''Herpes simplex virus protease'''
Line 100: Line 102:
**[[2jqf]], [[2j92]], [[5hm2]] – FMDV (mutant) <br />
**[[2jqf]], [[2j92]], [[5hm2]] – FMDV (mutant) <br />
**[[2wv4]], [[2wv5]] – FMDV (mutant) + peptide <br />
**[[2wv4]], [[2wv5]] – FMDV (mutant) + peptide <br />
 +
**[[1qmy]], [[1qol]] – FMDV residues 29-201 (mutant) <br />
 +
**[[4qbb]] – FMDV residues 29-201 + inhibitor <br />
*'''Infectious Bronchitis virus protease'''
*'''Infectious Bronchitis virus protease'''
-
**[[2q6d]], [[4x2z]] – IBV – infectious bronchitis virus <br />
+
**[[2q6d]], [[4x2z]] – IBV Ns3 – infectious bronchitis virus <br />
**[[2q6f]] – IBV + inhibitor
**[[2q6f]] – IBV + inhibitor
Line 115: Line 119:
**[[6urv]] – NS2B + NS3 <br />
**[[6urv]] – NS2B + NS3 <br />
 +
**[[5ffm]] – NS3 <br />
*'''Zika virus protease'''
*'''Zika virus protease'''
-
**[[6um3]], [[6jpw]] – NS2B + NS3 <br />
+
**[[5gj4]], [[5gxj]], [[5t1v]], [[5tfn]], [[6um3]], [[6jpw]] – NS2B + NS3 <br />
 +
**[[5tfo]], [[6um3]] – NS2B + NS3 (mutant)<br />
 +
**[[5jmt]], [[5jps]], [[5jrz]], [[5jwh]], [[5txg]], [[5vi7]], [[6adw]], [[6mh3]] – NS3 <br />
 +
**[[5k8i]], [[5k8l]], [[5k8t]], [[5k8u]], [[5y4z]], [[5y6m]], [[6adx]], [[6ady]], [[6rwz]], [[6s0j]] – NS3 + nucleotide <br />
 +
**[[5gjb]], [[5mfx]] – NS3 + RNA <br />
 +
**[[5rhg]], [[5rhh]], [[5rhi]], [[5rhj]], [[5rhk]], [[5rhl]], [[5rhm]], [[5rho]], [[5rhp]], [[5rhq]], [[5rhr]], [[5rhs]], [[5rht]], [[5rhu]], [[5rhv]], [[5rhw]], [[5rhx]], [[5rhy]]– NS3 + inhibitor<br />
 +
**[[5gjc]], [[5gpi]], [[5h4i]], [[5h6v]], [[5lc0]], [[5yod]], [[5yof]], [[5zmq]], [[5zms]], [[5zob]], [[6jpw]], [[6kk2]], [[6kk3]], [[6kk4]], [[6kk5]], [[6kk6]], [[6kpq]], [[6l4z]], [[6l50]], [[6y3b]] – NS2B + NS3 + inhibitor<br />
*'''Pseudorabies virus protease'''
*'''Pseudorabies virus protease'''
Line 126: Line 137:
*'''Coxsakievirus protease'''
*'''Coxsakievirus protease'''
-
**[[2vb0]], [[2zty]], [[2ztz]], [[3zyd]], [[3sj8]] – CSVP <br />
+
**[[4mg3]] – CSVP A2 863-1007 - Coxsakievirus A16 <br />
-
**[[2zu1]], [[3zye]], [[3zz3]], [[3zz4]] – CSVP (mutant) <br />
+
**[[3sj8]] – CSVP 3C 1-183 <br />
-
**[[2ztx]] – CSVP + Zn-H2S <br />
+
**[[2vb0]], [[2zty]], [[2ztz]], [[3zyd]] – CSVP 3C 14-196 - Coxsakievirus B3 <br />
-
**[[2zu3]], [[3zz5]], [[3zz6]], [[3zz7]], [[3zz8]], [[3zz9]], [[3zza]], [[3zzb]], [[3sji]] – CSVP + inhibitor <br />
+
**[[2zu1]], [[3zye]], [[3zz3]], [[3zz4]] – CSVP 3C (mutant) <br />
-
**[[3zzc]], [[3zzd]] – CSVP (mutant) + inhibitor <br />
+
**[[2ztx]] – CSVP 3C + Zn-H2S <br />
-
**[[3sj9]] – CSVP (mutant) + peptide inhibitor <br />
+
**[[2zu3]], [[3zz5]], [[3zz6]], [[3zz7]], [[3zz8]], [[3zz9]], [[3zza]], [[3zzb]], [[3sji]], [[5nfs]] – CSVP 3C + inhibitor <br />
 +
**[[3zzc]], [[3zzd]] – CSVP 3C (mutant) + inhibitor <br />
 +
**[[3sj9]] – CSVP 3C (mutant) + peptide inhibitor <br />
-
*'''Human polio virus protease'''
+
*'''Human poliovirus 3C protease'''
**[[1l1n]] – HPV <br />
**[[1l1n]] – HPV <br />
**[[2ijd]] – HPV (mutant) <br />
**[[2ijd]] – HPV (mutant) <br />
 +
**[[4dcd]] – HPV + peptide inhibitor <br />
*'''Human rhinovirus protease'''
*'''Human rhinovirus protease'''
-
**[[2in2]] – HRVP – human rhinovirus - NMR <br />
+
**[[2in2]], [[2m5t]] – HRVP – human rhinovirus A2 - NMR <br />
**[[1cqq]], [[2xya]], [[5fx5]], [[5fx6]], [[6ffn]], [[6ffs]] – HRVP + inhibitor <br />
**[[1cqq]], [[2xya]], [[5fx5]], [[5fx6]], [[6ffn]], [[6ffs]] – HRVP + inhibitor <br />
 +
**[[6kyz]], [[6kz0]] – HRVP + antibody – human rhinovirus B14 <br />
**[[2b0f]] – HRVP + inhibitor – NMR <br />
**[[2b0f]] – HRVP + inhibitor – NMR <br />
-
**[[2h6m]] – HRVP + peptide inhibitor <br />
+
**[[6ku7]] – HRVP – human rhinovirus C<br />
 +
**[[6ku8]] – HRVP + drug <br />
 +
**[[5x45]] – HRVP 2A – human rhinovirus C15 <br />
-
*'''Human enterovirus protease'''
+
*'''Human enterovirus protease A71'''
-
**[[3osy]] – HEVP 71 – human enterovirus <br />
+
**[[3osy]], [[4ghq]], [[8cny]] – HEVP <br />
-
**[[3zv8]] – HEVP 68 residues 1549-1731 <br />
+
**[[3r0f]] – HEVP (mutant) <br />
-
**[[3q3x]] – HEVP B (mutant) <br />
+
**[[3sjk]] – HEVP (mutant) + peptide inhibitor <br />
-
**[[3q3y]] – HEVP B (mutant) + inhibitor <br />
+
**[[4ght]], [[5bpe]], [[5c1u]], [[5c1x]], [[5c1y]], [[5c20]], [[5dp3]], [[5dp4]], [[5dp5]], [[5dp6]], [[5dp7]], [[5dp8]], [[5dp9]], [[5dpa]], [[5gso]], [[5gsw]], [[5hxf]], [[5wq2]], [[6lka]], [[7dnc]] – HEVP + inhibitor <br />
-
**[[3ruo]] – HEVP B + inhibitor <br />
+
**[[3sjo]], [[5hxf]], [[5wq2]] – HEVP + drug <br />
-
**[[3sjk]] – HEVP 71 (mutant) + peptide inhibitor <br />
+
**[[3qzq]], [[3qzr]], [[3r0f]] – HEVP (mutant) + drug <br />
-
**[[3sjo]], [[5bpe]], [[5hxf]], [[5wq2]] – HEVP 71 + inhibitor <br />
+
 
-
**[[3qzq]], [[3qzr]] – HEVP 71 (mutant) + inhibitor <br />
+
*'''Human enterovirus protease B'''
-
**[[3zv9]], [[3zva]], [[3zvb]], [[3zvc]], [[3zvd]], [[3zve]], [[3zvf]], [[3zvg]] – HEVP 68 + inhibitor <br />
+
 
 +
**[[3q3x]] – HEVP (mutant) <br />
 +
**[[3q3y]] – HEVP (mutant) + inhibitor <br />
 +
**[[3ruo]] – HEVP + drug <br />
 +
 
 +
*'''Human enterovirus protease D68'''
 +
 
 +
**[[3zv8]], [[8cnx]] – HEVP residues 1549-1731 <br />
 +
**[[8fl5]] – HEVP (mutant) <br />
 +
**[[3zv9]], [[3zva]], [[3zvb]], [[3zvc]], [[3zvd]], [[3zve]], [[3zvf]], [[3zvg]], [[7gnv]], [[7gnw]], [[7gnx]], [[7gny]], [[7gnz]], [[7go0]], [[7go1]], [[7go2]], [[7go3]], [[7go4]], [[7go5]], [[7go6]], [[7go7]], [[7go8]], [[7go9]], [[7goa]], [[7gob]], [[7goc]], [[7god]], [[7goe]], [[7gof]], [[7gog]], [[7goh]], [[7goi]], [[7goj]], [[7gok]], [[7gol]], [[7gom]], [[7gon]], [[7goo]], [[7gop]], [[7goq]], [[7gor]], [[7got]], [[7gou]], [[7gov]], [[7gow]], [[7gox]], [[7goy]], [[7goz]], [[7gp0]], [[7gp1]], [[7gp2]], [[7gp3]], [[7gp4]], [[7gp5]], [[7gp6]], [[7gp7]], [[7gp8]], [[7gp9]], [[7gpa]], [[7gpc]], [[7gpd]], [[7gpe]], [[7gpf]], [[7gpg]], [[7gph]], [[7gpi]], [[7gpj]], [[7gpl]], [[7gpm]], [[7gpn]], [[7gpo]], [[7gpp]], [[7gpq]], [[7gpr]], [[7gps]], [[7gpt]], [[7gpu]], [[7gpv]], [[7gpw]], [[7gpx]], [[7gpy]], [[7gpz]], [[7gq0]], [[7gq1]], [[7gq2]], [[7gq3]], [[7gq4]], [[7gq6]], [[7gq7]], [[7gq8]], [[7gq9]], [[7gqa]], [[7gqb]], [[7gqc]], [[7gqd]], [[7gqe]], [[7gqf]], [[7gqh]], [[7gqi]], [[7gqj]], [[7gqk]], [[7gql]], [[7gqm]], [[7gqn]], [[7gqo]], [[7gqp]], [[7gqq]], [[7gqr]] – HEVP + inhibitor <br />
 +
**[[7l8h]] – HEVP + drug <br />
*'''Porcine epidemic diarrhea virus protease'''
*'''Porcine epidemic diarrhea virus protease'''
-
**[[5hyo]], [[6noz]] – PEDVP – porcine epidemic diarrhea virus <br />
+
**[[4xfq]], [[5hyo]], [[6noz]] – PEDVP – porcine epidemic diarrhea virus <br />
 +
**[[6l70]] – PEDVP + inhibitor<br />
 +
**[[4zuh]] – PEDVP (mutant)+ inhibitor<br />
*'''Echovirus 1 protease'''
*'''Echovirus 1 protease'''
Line 165: Line 194:
**[[5iyt]] – EV1P (mutant) + inhibitor – Echovirus 1 <br />
**[[5iyt]] – EV1P (mutant) + inhibitor – Echovirus 1 <br />
-
*'''Gastroentritis virus protease'''
+
*'''Transmissible Gastroenteritis virus protease'''
-
**[[2amp]] – GEVP + inhibitor – gastroenteritis virus <br />
+
**[[2amp]] – TGEVP + inhibitor <br />
*'''Southampton virus protease'''
*'''Southampton virus protease'''
-
**[[2iph]] – SVP + inhibitor – Southampton virus <br />
+
**[[6t1q]] – SVP – Southampton virus <br />
 +
**[[2iph]], [[6t2i]], [[6t2x]], [[6t3g]], [[6t49]], [[6t4e]], [[6t4s]], [[6t5d]], [[6t5r]], [[6t6w]], [[6t71]], [[6t82]], [[6t8r]], [[6t8t]], [[6tal]], [[6taw]], [[6tbo]], [[6tbp]], [[6tc1]], [[6tcf]], [[6tgl]] – SVP + inhibitor<br />
*'''West Nile virus protease'''
*'''West Nile virus protease'''
-
**[[2ggv]] - WNVP (mutant) - West Nile virus<br />
+
**[[2ggv]] - WNVP Ns2B/Ns3 (mutant) - West Nile virus<br />
-
**[[2ijo]] - WNVP (mutant) + BPTI<br />
+
**[[2ijo]] - WNVP Ns2B/Ns3 (mutant) + BPTI<br />
-
**[[2yol]], [[5idk]], [[2fp7]] - WNVP + peptide inhibitor<br />
+
**[[2yol]], [[5idk]], [[2fp7]] - WNVP Ns2B/Ns3 + peptide inhibitor<br />
-
**[[3e90]] - WNVP + inhibitor<br />
+
**[[3e90]] - WNVP Ns2B/Ns3 + inhibitor<br />
*'''African swine fever virus protease'''
*'''African swine fever virus protease'''
Line 184: Line 214:
**[[6ljb]], [[6lj9]] – ASFV – African swine fever virus<br />
**[[6ljb]], [[6lj9]] – ASFV – African swine fever virus<br />
-
*'''Norovirus protease residues 1101-1281'''
+
*'''Senecavirus 3C protease residues 1509-1719'''
 +
 
 +
**[[6l0t]] – 3CP<br />
 +
 
 +
*'''Norovirus 3C-like protease residues 1-173'''
 +
 
 +
**[[1wqs]] – 3CLP<br />
 +
 
 +
*'''Norovirus 3C-like protease residues 1101-1281'''
**[[2fyq]], [[2fyr]], [[3ur6]] – 3CLP<br />
**[[2fyq]], [[2fyr]], [[3ur6]] – 3CLP<br />
**[[2lnc]] – 3CLP - NMR<br />
**[[2lnc]] – 3CLP - NMR<br />
-
**[[2iph]] – 3CLP + peptide <br />
+
**[[2iph]], [[3ur9]], [[4imq]] – 3CLP + peptide inhibitor<br />
-
**[[5dg6]], [[5dgj]], [[5e0g]], [[5e0h]], [[5e0j]], [[5t6d]], [[5t6f]], [[5t6g]], [[5t61]], [[5t62]], [[4imq]], [[4imz]], [[4in1]], [[4in2]], [[4inh]], [[3ur9]], [[4xbb]], [[4xbc]], [[4xbd]], [[5wej]] – 3CLP + inhibitor <br />
+
**[[3ur9]], [[4imz]], [[4in1]], [[4in2]], [[4inh]], [[4xbb]], [[4xbc]], [[4xbd]], [[5t61]], [[5t62]], [[5t6d]], [[5t6f]], [[5t6g]], [[5wej]], [[6w5h]], [[6w5j]], [[6w5k]], [[6w5l]] – 3CLP + inhibitor <br />
-
**[[1wqs]] – 3CLP residues 1-173 + Hg
+
**[[5dg6]], [[5dgj]], [[5e0g]], [[5e0h]], [[5e0j]], [[5tg1]], [[5tg2]], [[6bib]], [[6bic]], [[6bid]] – 3CLP + macrocyclic inhibitor <br />
 +
**[[6b6i]] – 3CLP residues 982-1162 (mutant) - human norovirus GII<br />
 +
**[[6nir]] – HOV<br />
*Mouse Norovirus protease residues 995-1177
*Mouse Norovirus protease residues 995-1177
Line 198: Line 238:
*'''SARS human corona virus 3C-like protease C-terminal 3241-3546'''
*'''SARS human corona virus 3C-like protease C-terminal 3241-3546'''
-
**[[1q2w]], [[2gt7]], [[1z1i]], [[2a5a]], [[2c3s]], [[2bx3]], [[2bx4]] , [[1uj1]], [[1uk2]], [[1uk3]], [[2duc]] – 3CLP – SARS-COV<br />
+
**[[1q2w]], [[1uj1]], [[1uk2]], [[1uk3]], [[1z1i]], [[2a5a]], [[2bx3]], [[2c3s]], [[2bx3]], [[2bx4]], [[2duc]], [[2gt7]], [[3ebn]], [[3vb3]], [[5r8t]], [[6m2q]], [[6wqf]], [[6xb0]], [[6xb1]], [[6xb2]], [[6xhu]], [[6y2e]], [[7ar5]], [[7ar6]], [[7bro]], [[7dqz]], [[7jp1]], [[7jpy]], [[7jun]], [[7k3t]], [[7kfi]], [[7lfp]], [[7khp]] – 3CLP – SARS-COV<br />
-
**[[5b6o]], [[3m3s]], [[3m3t]], [[3m3v]], [[3fzd]], [[3f9e]], [[3f9f]], [[3f9g]], [[3f9h]], [[3ea7]], [[3ea8]], [[3ea9]], [[3eaj]], [[3e91]], [[3ee7]], [[2qc2]], [[2qcy]], [[2pwx]], [[2gt8]], [[1z1j]], [[3aw1]] – 3CLP (mutant) – SARS-COV<br />
+
**[[1z1j]], [[2gt8]], [[2pwx]], [[2q6g]], [[2qc2]], [[2qcy]], [[3m3s]], [[3m3t]], [[3m3v]], [[3fzd]], [[3f9e]], [[3f9f]], [[3f9g]], [[3f9h]], [[3ea7]], [[3ea8]], [[3ea9]], [[3eaj]], [[3e91]], [[3ee7]], [[3aw1]], [[4hi3]], [[5b6o]], [[7joy]], [[7n6n]], [[7t2v]] – 3CLP (mutant) – SARS-COV<br />
**[[2liz]] – 3CLP – SARS-COV - NMR<br />
**[[2liz]] – 3CLP – SARS-COV - NMR<br />
-
**[[3ebn]] – 3CLP C-terminal 3429-3546<br />
+
**[[6wtj]], [[6wtk]], [[6wtm]], [[6xqs]], [[6xqt]], [[6xqu]], [[7aol]], [[7b83]], [[7brp]], [[7buy]], [[7c6s]], [[7jyc]], [[7k6d]], [[7k6e]] – 3CLP + drug – hCOV-2<br />
**[[3d23]] – 3CLP + inhibitor – hCOV-HKU1<br />
**[[3d23]] – 3CLP + inhibitor – hCOV-HKU1<br />
-
**[[5gwy]] – 3CLP + inhibitor – hCOV-NL63<br />
+
**[[3tlo]], [[7e6l]], [[7e6m]], [[7e6n]], [[7e6r]] – NL633CLP 2940-3242 – hCOV-NL63<br />
-
**[[2amd]], [[2amq]], [[2amp]], [[1wof]], [[2ynb]], [[3atw]], [[3avz]], [[3iwm]], [[4yw3]], [[4tww]], [[4twy]] – 3CLP + inhibitor – SARS-COV<br />
+
**[[5gwy]], [[7eov]] – NL633CLP + inhibitor <br />
-
**[[5c5n]], [[5c5o]] – 3CLP (mutant) + inhibitor – SARS-COV<br />
+
**[[1wof]], [[2amd]], [[2amq]], [[2amp]], [[2gx4]], [[2gz7]], [[2gz8]], [[2op9]], [[2ops]], [[2vj1]], [[2ynb]], [[2z94]], [[3atw]], [[3avz]], [[3d62]], [[3iwm]], [[3sn8]], [[3v3m]], [[4tww]], [[4twy]], [[4wy3]], [[5re4]], [[5re5]], [[5re6]], [[5re7]], [[5re8]], [[5re9]], [[5rea]], [[5reb]], [[5rec]], [[5red]], [[5ree]], [[5ref]], [[5reg]], [[5rep]], [[5rer]], [[5res]], [[5ret]], [[5reu]], [[5rew]], [[5rex]], [[5rey]], [[5rez]], [[5rf1]], [[5rf2]], [[5rf3]], [[5rf4]], [[5rf5]], [[5rf6]], [[5rf9]], [[5rfa]], [[5rfb]], [[5rfc]], [[5rfd]], [[5rfe]], [[5rff]], [[5rfg]], [[5rfh]], [[5rg1]], [[5rg2]], [[5rg3]], [[5rgg]], [[5rgh]], [[5rgi]], [[5rgj]], [[5rgk]], [[5rgl]], [[5rgm]], [[5rgn]], [[5rgo]], [[5rgp]], [[5rgq]], [[5rgr]], [[5rgs]], [[6lnq]], [[6lny]], [[6lo0]], [[6lu7]], [[6lze]], [[6m0k]], [[6m2n]], [[6w2a]], [[6w63]], [[6w79]], [[6wco]], [[6xhl]], [[6xhm]], [[6xhn]], [[6xho]], [[6xmk]], [[7a1u]], [[7aga]], [[7aha]], [[7amj]], [[7bqy]], [[7c6u]], [[7d1m]], [[7jkv]], [[7jpz]], [[7jq0]], [[7jq1]], [[7jq2]], [[7jq3]], [[7jq4]], [[7jq5]], [[7k0e]], [[7k0f]], [[7k0g]], [[7k0h]], [[7ldx]], [[7vic]], [[7xar]], [[8uld]] – 3CLP + inhibitor – SARS-COV<br />
-
**[[2vj1]], [[3tit]], [[3tiu]] – 3CLP + unsaturated ester
+
**[[5c5n]], [[5c5o]], [[8h6i]] – 3CLP (mutant) + inhibitor – SARS-COV<br />
-
**[[2zu2]], [[2zu4]], [[2zu5]], [[3tns]], [[3tnt]], [[3aw0]] – 3CLP + peptidomimetic compound<br />
+
**[[2vj1]], [[3tit]], [[3tiu]] – 3CLP + unsaturated ester<br />
-
**[[3d62]] – 3CLP + halometyl ketone inhibitor<br />
+
**[[2zu2]], [[2zu4]], [[2zu5]], [[3aw0]], [[3tns]], [[3tnt]], [[3vb4]], [[3vb5]], [[3vb6]], [[3vb7]], [[7t2u]] – 3CLP + peptidomimetic compound<br />
**[[2z9g]] – 3CLP + benzene + Hg<br />
**[[2z9g]] – 3CLP + benzene + Hg<br />
**[[2z9j]], [[2z9k]], [[2z9l]] – 3CLP + Zn compound<br />
**[[2z9j]], [[2z9k]], [[2z9l]] – 3CLP + Zn compound<br />
-
**[[2ops]] – 3CLP + phenylalanine derivative inhibitor<br />
+
**[[1uk4]], [[2z3c]], [[2z3d]], [[2z3e]], [[2gx4]], [[3sna]], [[3snb]], [[3snc]], [[3snd]], [[3sne]], [[6xch]] – 3CLP + peptide inhibitor<br />
-
**[[2z3c]], [[2z3d]], [[2z3e]], [[2gx4]], [[1uk4]] – 3CLP + peptide inhibitor<br />
+
**[[2gtb]] - 3CLP (mutant) + aza-peptide epoxide inhibitor<br />
**[[2gtb]] - 3CLP (mutant) + aza-peptide epoxide inhibitor<br />
**[[2a5i]], [[2a5k]] - 3CLP + aza-peptide epoxide inhibitor<br />
**[[2a5i]], [[2a5k]] - 3CLP + aza-peptide epoxide inhibitor<br />
Line 221: Line 260:
**[[4zro]] – 3CLP + inhibitor – cat COV<br />
**[[4zro]] – 3CLP + inhibitor – cat COV<br />
**[[2yna]] – 3CLP + inhibitor – bat COV-HKU4<br />
**[[2yna]] – 3CLP + inhibitor – bat COV-HKU4<br />
 +
 +
*'''SARS human corona virus papain-like protease C-terminal 1564-1878'''
 +
 +
**[[6w9c]] – PLpro<br />
 +
**[[7cjd]], [[7d6h]] – PLpro (mutant) <br />
 +
**[[5tl6]], [[5tl7]], [[6xa9]], [[6xaa]], [[6yva]] – PLpro (mutant) + mISG15<br />
 +
**[[3e9s]], [[3mj5]], [[7cjm]], [[7cmd]] – PLpro + inhibitor<br />
 +
**[[7e35]], [[7jrn]] – PLpro (mutant) + inhibitor<br />
 +
**[[6wuu]], [[6wx4]] – PLpro + peptide inhibitor<br />
 +
**[[4mm3]], [[5e6j]] – PLpro + ubiquitin<br />
 +
**[[4m0w]] – PLpro (mutant) + ubiquitin<br />
*'''MERS corona virus protease C-terminal 3248-3553'''
*'''MERS corona virus protease C-terminal 3248-3553'''
-
**[[5c3n]] – ORF1A<br />
+
**[[5c3n]], [[5ko3]] – ORF1A<br />
-
**[[4wmd]], [[4wme]], [[4wmf]] – ORF1A (mutant)<br />
+
**[[4wmd]], [[4wme]], [[4wmf]], [[8e7t]] – ORF1A (mutant)<br />
-
**[[4ylu]] – ORF1A + inhibitor<br />
+
**[[4ylu]], [[5wkj]], [[5wkk]], [[5wkl]], [[5wkm]], [[6vgy]], [[6vgz]], [[6vh0]], [[6vh1]], [[6vh2]], [[6vh3]] – ORF1A + inhibitor<br />
-
**[[5hih]] – ORF1A X domain 1109-1275<br />
+
**[[4rsp]], [[7d3c]] – ORF1A + peptide inhibitor<br />
 +
**[[5zu7]], [[5zu9]], [[5zua]] – ORF1A + nucleotide<br />
 +
**[[5zub]] – ORF1A + NAD<br />
 +
**[[5hih]] – ORF1A macro domain 1109-1275<br />
 +
**[[5dus]], [[5hol]] – ORF1A macro domain + ADP-ribose<br />
*'''MERS corona virus papain-like protease domain 1480-1811'''
*'''MERS corona virus papain-like protease domain 1480-1811'''
Line 238: Line 292:
**[[4wur]] – ORF1AB (mutant) + ubiquitin <br />
**[[4wur]] – ORF1AB (mutant) + ubiquitin <br />
 +
*'''Mason-pfizer monkey virus protease '''
 +
 +
**[[7bgt]], [[7bgu]] – MPMVP + inhibitor <br />
 +
*'''Maize rayado fino virus protease '''
 +
**[[7mia]] – MRFVP + inhibitor <br />
 +
**[[7mic]] – MRFVP + ubiquitin<br />
}}
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Updated on 03-April-2024 - For a general description of the protein see Virus protease

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Jaime Prilusky

Retrieved from "http://52.214.119.220/wiki/index.php/Virus_protease_3D_structures"
Personal tools