Coatomer

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<StructureSection load='5nzu' size='350' side='right' caption='Mouse COPI coat complex containing subunits alpha (grey), beta (green), beta prime (pink), delta (yellow), gamma-1 (red), zeta-1 (aqua) and protein Arf-1 (cyan) (PDB entry [[5nzu]])' scene=>
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<StructureSection load='5nzu' size='350' side='right' caption='Mouse COPI coat complex containing subunits alpha (grey), beta (green), beta prime (pink), delta (yellow), gamma-1 (red), zeta-1 (aqua) and protein Arf-1 (cyan) (PDB entry [[5nzu]])' scene='10/1041515/Cv/2'>
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'''Coatomers''' (COPI) are a set of vesicles' coating proteins <ref>PMID:898986</ref>. Coatomers contain several subunits which are named according to decreasing molecular weight as alpha, beta', gamma, delta, epsilon and zeta-1. Protein ADP-ribosylation factor 1 (Arf-1) is part of the vesicle-coating complex<ref>PMID:9681627</ref>.
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'''Coatomers''' (COPI) are a set of vesicles' coating proteins <ref>PMID:1898986</ref>. Coatomers contain several subunits which are named according to decreasing molecular weight as alpha, beta', gamma, delta, epsilon and zeta-1. Protein ADP-ribosylation factor 1 (Arf-1) is part of the vesicle-coating complex<ref>PMID:9681627</ref>.
== Function ==
== Function ==
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COPI function in the sorting and trafficking of proteins between sub cellular organelles <ref>PMID:34450031</ref>. COP1 induces membrane curvature during budding<ref>PMID:21893600</ref>. Dilysine motifs on transmembrane proteins are recognised by COPI alpha and beta' subunits and packaged into COPI-coated vesicles for transport from Golgi to ER<ref>PMID:23481256</ref>.
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COPI function in the sorting and trafficking of proteins between sub cellular organelles <ref>PMID:34450031</ref>. COP1 induces membrane curvature during budding<ref>PMID:21893600</ref>. Dilysine motifs on transmembrane proteins are recognised by COPI alpha and beta' subunits and packaged into COPI-coated vesicles for transport from Golgi to ER<ref>PMID:23481256</ref>.
== Disease ==
== Disease ==
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Mutations in COPI can result in osteoporosis, fractures and developmental delays. Deficiency in COPI alpha subunit cause COPA syndrome<ref>PMID:3584149</ref>.
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Mutations in COPI can result in osteoporosis, fractures and developmental delays. Deficiency in COPI alpha subunit cause COPA syndrome<ref>PMID:30804679</ref>.
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== Relevance ==
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== Structural highlights ==
== Structural highlights ==
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This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
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The <scene name='10/1041515/Cv/3'>COPI/Arf-1 complex</scene> consists of subunit alpha, subunit beta, subunit beta', subunit gamma-1, subunit delta, subunit zeta-1 and protein Arf-1<ref>PMID:28621666</ref>.
==Coatomer 3D structures==
==Coatomer 3D structures==

Current revision

Mouse COPI coat complex containing subunits alpha (grey), beta (green), beta prime (pink), delta (yellow), gamma-1 (red), zeta-1 (aqua) and protein Arf-1 (cyan) (PDB entry 5nzu)

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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