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1a9g

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[[Image:1a9g.gif|left|200px]]<br /><applet load="1a9g" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1a9g" />
 
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'''APURINIC DNA WITH BOUND WATER AT THE DAMAGED SITE AND N3 OF CYTOSINE, BETA FORM, NMR, 1 STRUCTURE'''<br />
 
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==Overview==
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==APURINIC DNA WITH BOUND WATER AT THE DAMAGED SITE AND N3 OF CYTOSINE, BETA FORM, NMR, 1 STRUCTURE==
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Natural and exogenous processes can give rise to abasic sites with either a purine or pyrimidine as the base on the opposing strand. The solution state structures of the apyrimidinic DNA duplex, with D6 indicating an abasic site, [sequence: see text] referred to as AD, and the apurinic DNA duplex with a dC17, referred to as CD, have been determined. A particularly striking difference is that the abasic site in CD is predominantly a beta hemiacetal, whereas in AD the alpha and beta forms are equally present. Hydrogen bonding with water by the abasic site and the base on the opposite strand appears to play a large role in determining the structure near the damaged site. Comparison of these structures with that of a duplex DNA containing a thymine glycol at the same position as the abasic site and with that of a duplex DNA containing an abasic site in the middle of a curved DNA sequence offers some insight into the common and distinct structural features of damaged DNA sites.
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<StructureSection load='1a9g' size='340' side='right'caption='[[1a9g]]' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1a9g]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A9G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A9G FirstGlance]. <br>
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1A9G is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A9G OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AAB:2-DEOXY-RIBOFURANOSE-5-MONOPHOSPHATE'>AAB</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a9g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a9g OCA], [https://pdbe.org/1a9g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a9g RCSB], [https://www.ebi.ac.uk/pdbsum/1a9g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a9g ProSAT]</span></td></tr>
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Structures of apurinic and apyrimidinic sites in duplex DNAs., Beger RD, Bolton PH, J Biol Chem. 1998 Jun 19;273(25):15565-73. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9624147 9624147]
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</table>
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[[Category: Protein complex]]
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__TOC__
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[[Category: Beger, R D.]]
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</StructureSection>
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[[Category: Bolton, P H.]]
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[[Category: Large Structures]]
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[[Category: apurinic dna]]
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[[Category: Beger RD]]
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[[Category: damaged dna]]
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[[Category: Bolton PH]]
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[[Category: water]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:42:18 2008''
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Current revision

APURINIC DNA WITH BOUND WATER AT THE DAMAGED SITE AND N3 OF CYTOSINE, BETA FORM, NMR, 1 STRUCTURE

PDB ID 1a9g

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