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1lri

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(New page: 200px<br /><applet load="1lri" size="450" color="white" frame="true" align="right" spinBox="true" caption="1lri, resolution 1.45&Aring;" /> '''BETA-CRYPTOGEIN-CHOL...)
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[[Image:1lri.gif|left|200px]]<br /><applet load="1lri" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1lri, resolution 1.45&Aring;" />
 
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'''BETA-CRYPTOGEIN-CHOLESTEROL COMPLEX'''<br />
 
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==Overview==
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==BETA-CRYPTOGEIN-CHOLESTEROL COMPLEX==
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Cryptogein is a small 10 kDa elicitor produced by the phytoparasitic, oomycete Phytophthora cryptogea. The protein also displays a sterol, carrier activity. The native protein crystallizes in space group P4(1)22, with unit-cell parameters a = b = 46.51, c = 134.9 A (diffraction limit:, 2.1 A). Its complex with cholesterol crystallizes in space group C222(1), with unit-cell parameters a = 30.96, b = 94.8, c = 65.3 A and a resolution, enhanced to 1.45 A. The large inner non-specific hydrophobic cavity is, able to accommodate a large variety of 3-beta-hydroxy sterols. Cryptogein, probably acts as a sterol shuttle helping the pathogen to grow and, complete its life cycle.
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<StructureSection load='1lri' size='340' side='right'caption='[[1lri]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1lri]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Phytophthora_cryptogea Phytophthora cryptogea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LRI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LRI FirstGlance]. <br>
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1LRI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Phytophthora_cryptogea Phytophthora cryptogea] with CL and CLR as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1LRI OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lri FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lri OCA], [https://pdbe.org/1lri PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lri RCSB], [https://www.ebi.ac.uk/pdbsum/1lri PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lri ProSAT]</span></td></tr>
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The 1.45 A resolution structure of the cryptogein-cholesterol complex: a close-up view of a sterol carrier protein (SCP) active site., Lascombe MB, Ponchet M, Venard P, Milat ML, Blein JP, Prange T, Acta Crystallogr D Biol Crystallogr. 2002 Sep;58(Pt 9):1442-7. Epub 2002, Aug 23. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12198300 12198300]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ELIB_PHYCR ELIB_PHYCR] Induces local and distal defense responses (incompatible hypersensitive reaction) in plants from the solanaceae and cruciferae families. Elicits leaf necrosis and causes the accumulation of pathogenesis-related proteins. Might interact with the lipidic molecules of the plasma membrane.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lr/1lri_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lri ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Phytophthora cryptogea]]
[[Category: Phytophthora cryptogea]]
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[[Category: Single protein]]
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[[Category: Blein J-P]]
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[[Category: Blein, J.P.]]
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[[Category: Lascombe M-B]]
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[[Category: Lascombe, M.B.]]
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[[Category: Milat M-L]]
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[[Category: Milat, M.L.]]
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[[Category: Ponchet M]]
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[[Category: Ponchet, M.]]
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[[Category: Prange T]]
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[[Category: Prange, T.]]
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[[Category: Venard P]]
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[[Category: Venard, P.]]
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[[Category: CL]]
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[[Category: CLR]]
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[[Category: cholesterol]]
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[[Category: cryptogein]]
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[[Category: sterol carrier protein]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 20:48:35 2007''
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Current revision

BETA-CRYPTOGEIN-CHOLESTEROL COMPLEX

PDB ID 1lri

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