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1lsl

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(New page: 200px<br /> <applet load="1lsl" size="450" color="white" frame="true" align="right" spinBox="true" caption="1lsl, resolution 1.90&Aring;" /> '''Crystal Structure o...)
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[[Image:1lsl.gif|left|200px]]<br />
 
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<applet load="1lsl" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1lsl, resolution 1.90&Aring;" />
 
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'''Crystal Structure of the Thrombospondin-1 Type 1 Repeats'''<br />
 
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==Overview==
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==Crystal Structure of the Thrombospondin-1 Type 1 Repeats==
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Thrombospondin-1 (TSP-1) contains three type 1 repeats (TSRs), which, mediate cell attachment, glycosaminoglycan binding, inhibition of, angiogenesis, activation of TGFbeta, and inhibition of matrix, metalloproteinases. The crystal structure of the TSRs reported in this, article reveals a novel, antiparallel, three-stranded fold that consists, of alternating stacked layers of tryptophan and arginine residues from, respective strands, capped by disulfide bonds on each end. The front face, of the TSR contains a right-handed spiral, positively charged groove that, might be the "recognition" face, mediating interactions with various, ligands. This is the first high-resolution crystal structure of a TSR, domain that provides a prototypic architecture for structural and, functional exploration of the diverse members of the TSR superfamily.
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<StructureSection load='1lsl' size='340' side='right'caption='[[1lsl]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1lsl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LSL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LSL FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lsl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lsl OCA], [https://pdbe.org/1lsl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lsl RCSB], [https://www.ebi.ac.uk/pdbsum/1lsl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lsl ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TSP1_HUMAN TSP1_HUMAN] Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties.<ref>PMID:11134179</ref> <ref>PMID:15014436</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ls/1lsl_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lsl ConSurf].
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<div style="clear:both"></div>
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==Disease==
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==See Also==
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Known disease associated with this structure: Sudden infant death with dysgenesis of the testes syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604714 604714]]
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*[[Thrombospondin|Thrombospondin]]
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== References ==
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==About this Structure==
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<references/>
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1LSL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with FUL and FUC as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1LSL OCA].
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__TOC__
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</StructureSection>
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==Reference==
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Crystal structure of the TSP-1 type 1 repeats: a novel layered fold and its biological implication., Tan K, Duquette M, Liu JH, Dong Y, Zhang R, Joachimiak A, Lawler J, Wang JH, J Cell Biol. 2002 Oct 28;159(2):373-82. Epub 2002 Oct 21. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12391027 12391027]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Dong, Y.]]
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[[Category: Dong Y]]
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[[Category: Duquette, M.]]
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[[Category: Duquette M]]
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[[Category: Joachimiak, A.]]
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[[Category: Joachimiak A]]
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[[Category: Lawler, J.]]
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[[Category: Lawler J]]
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[[Category: Liu, J.]]
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[[Category: Liu J]]
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[[Category: Tan, K.]]
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[[Category: Tan K]]
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[[Category: Wang, J.H.]]
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[[Category: Wang J-H]]
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[[Category: Zhang, R.]]
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[[Category: Zhang R]]
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[[Category: FUC]]
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[[Category: FUL]]
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[[Category: tsp-1]]
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[[Category: tsr]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 18:03:57 2007''
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Current revision

Crystal Structure of the Thrombospondin-1 Type 1 Repeats

PDB ID 1lsl

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