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1luz

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{{Seed}}
 
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[[Image:1luz.png|left|200px]]
 
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==Crystal Structure of the K3L Protein From Vaccinia Virus (Wisconsin Strain)==
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The line below this paragraph, containing "STRUCTURE_1luz", creates the "Structure Box" on the page.
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<StructureSection load='1luz' size='340' side='right'caption='[[1luz]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1luz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccinia_virus_WR Vaccinia virus WR]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LUZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LUZ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_1luz| PDB=1luz | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1luz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1luz OCA], [https://pdbe.org/1luz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1luz RCSB], [https://www.ebi.ac.uk/pdbsum/1luz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1luz ProSAT]</span></td></tr>
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</table>
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===Crystal Structure of the K3L Protein From Vaccinia Virus (Wisconsin Strain)===
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== Function ==
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[https://www.uniprot.org/uniprot/K3_VACCW K3_VACCW] Viral mimic of eIF-2-alpha that acts as a pseudosubstrate for EIF2AK2/PKR kinase. Inhibits therefore eIF-2-alpha phosphorylation by host EIF2AK2/PKR kinase and prevents protein synthesis shutoff.<ref>PMID:8099586</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_12191475}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 12191475 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lu/1luz_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_12191475}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1LUZ is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LUZ OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1luz ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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<ref group="xtra">PMID:12191475</ref><references group="xtra"/>
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<references/>
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[[Category: Vaccinia virus]]
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__TOC__
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[[Category: Dar, A C.]]
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</StructureSection>
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[[Category: Sicheri, F.]]
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[[Category: Large Structures]]
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[[Category: 5 stranded anti-parallel beta barrel]]
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[[Category: Vaccinia virus WR]]
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[[Category: Dar AC]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 02:39:16 2009''
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[[Category: Sicheri F]]

Current revision

Crystal Structure of the K3L Protein From Vaccinia Virus (Wisconsin Strain)

PDB ID 1luz

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