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1lv9

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(New page: 200px<br /> <applet load="1lv9" size="450" color="white" frame="true" align="right" spinBox="true" caption="1lv9" /> '''CXCR3 Binding Chemokine IP-10/CXCL10'''<br ...)
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[[Image:1lv9.gif|left|200px]]<br />
 
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<applet load="1lv9" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1lv9" />
 
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'''CXCR3 Binding Chemokine IP-10/CXCL10'''<br />
 
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==Overview==
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==CXCR3 Binding Chemokine IP-10/CXCL10==
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The structure of IP-10 was solved by NMR spectroscopy and represents the, first structure from the class of agonists toward the receptor CXCR3., CXCR3 binding chemokines are unique in their ability to bind receptors, from both the CC and CXC classes of chemokine receptors. An unusual, structural feature of IP-10 was identified that may provide the basis for, the ability of IP-10 to bind both CXCR3 and CCR3. The surface of IP-10, that interacts with the N-terminus of CXCR3 was defined by monitoring, changes in the NMR spectrum of IP-10 upon addition of a CXCR3 N-terminal, peptide. These studies indicated that the interaction involves a, hydrophobic cleft, formed by the N-loop and 40s-loop region of IP-10, similar to the interaction surface observed for other chemokines such as, IL-8. An additional region of interaction was observed that consists of a, hydrophobic cleft formed by the N-terminus of IP-10 and 30s-loop of IP-10.
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<StructureSection load='1lv9' size='340' side='right'caption='[[1lv9]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1lv9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LV9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LV9 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lv9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lv9 OCA], [https://pdbe.org/1lv9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lv9 RCSB], [https://www.ebi.ac.uk/pdbsum/1lv9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lv9 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CXL10_HUMAN CXL10_HUMAN] Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lv/1lv9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lv9 ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1LV9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1LV9 OCA].
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*[[C-X-C motif chemokine 3D structures|C-X-C motif chemokine 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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The CXCR3 binding chemokine IP-10/CXCL10: structure and receptor interactions., Booth V, Keizer DW, Kamphuis MB, Clark-Lewis I, Sykes BD, Biochemistry. 2002 Aug 20;41(33):10418-25. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12173928 12173928]
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[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Booth, V.]]
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[[Category: Booth V]]
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[[Category: Clark-Lewis, I.]]
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[[Category: Clark-Lewis I]]
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[[Category: Kamphuis, M.B.]]
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[[Category: Kamphuis MB]]
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[[Category: Keizer, D.W.]]
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[[Category: Keizer DW]]
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[[Category: Sykes, B.D.]]
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[[Category: Sykes BD]]
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[[Category: chemokine]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 18:04:29 2007''
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Current revision

CXCR3 Binding Chemokine IP-10/CXCL10

PDB ID 1lv9

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