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1lvb

From Proteopedia

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[[Image:1lvb.png|left|200px]]
 
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{{STRUCTURE_1lvb| PDB=1lvb | SCENE= }}
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==CATALYTICALLY INACTIVE TOBACCO ETCH VIRUS PROTEASE COMPLEXED WITH SUBSTRATE==
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<StructureSection load='1lvb' size='340' side='right'caption='[[1lvb]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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===CATALYTICALLY INACTIVE TOBACCO ETCH VIRUS PROTEASE COMPLEXED WITH SUBSTRATE===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1lvb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Tobacco_etch_virus Tobacco etch virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LVB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LVB FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12377789}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lvb OCA], [https://pdbe.org/1lvb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lvb RCSB], [https://www.ebi.ac.uk/pdbsum/1lvb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lvb ProSAT]</span></td></tr>
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[[1lvb]] is a 4 chain structure of [[Tobacco Etch Virus (TEV) Protease]] with sequence from [http://en.wikipedia.org/wiki/Tobacco_etch_virus Tobacco etch virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LVB OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/POLG_TEV POLG_TEV] Capsid protein: involved in aphid transmission, cell-to-cell and systemis movement, encapsidation of the viral RNA and in the regulation of viral RNA amplification.<ref>PMID:9880030</ref> <ref>PMID:11414807</ref> Nuclear inclusion protein B: an RNA-dependent RNA polymerase that plays an essential role in the virus replication.<ref>PMID:9880030</ref> <ref>PMID:11414807</ref> Helper component proteinase: required for aphid transmission and also has proteolytic activity. Only cleaves a Gly-Gly dipeptide at its own C-terminus. Interacts with virions and aphid stylets. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. May have RNA-binding activity.<ref>PMID:9880030</ref> <ref>PMID:11414807</ref> Cytoplasmic inclusion protein: has helicase activity. It may be involved in replication.<ref>PMID:9880030</ref> <ref>PMID:11414807</ref> Both 6K peptides are indispensable for virus replication (By similarity).<ref>PMID:9880030</ref> <ref>PMID:11414807</ref> Nuclear inclusion protein A: has RNA-binding and proteolytic activities.<ref>PMID:9880030</ref> <ref>PMID:11414807</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lv/1lvb_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lvb ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Ashley Steere/Tobacco Etch Virus (TEV) Protease|Ashley Steere/Tobacco Etch Virus (TEV) Protease]]
 
*[[Tobacco Etch Virus (TEV) Protease|Tobacco Etch Virus (TEV) Protease]]
*[[Tobacco Etch Virus (TEV) Protease|Tobacco Etch Virus (TEV) Protease]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:012377789</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Tobacco etch virus]]
[[Category: Tobacco etch virus]]
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[[Category: Evdokimov, A G.]]
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[[Category: Evdokimov AG]]
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[[Category: III, H K.Peters.]]
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[[Category: Kapust RB]]
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[[Category: Kapust, R B.]]
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[[Category: Li M]]
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[[Category: Li, M.]]
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[[Category: Peters III HK]]
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[[Category: Phan, J.]]
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[[Category: Phan J]]
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[[Category: Tropea, J E.]]
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[[Category: Tropea JE]]
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[[Category: Waugh, D S.]]
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[[Category: Waugh DS]]
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[[Category: Wlodawer, A.]]
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[[Category: Wlodawer A]]
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[[Category: Zdanov, A.]]
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[[Category: Zdanov A]]
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[[Category: Beta barrel]]
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[[Category: Chymotrypsin-like cystein protease]]
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[[Category: Protein-peptide complex]]
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[[Category: Viral protein]]
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Current revision

CATALYTICALLY INACTIVE TOBACCO ETCH VIRUS PROTEASE COMPLEXED WITH SUBSTRATE

PDB ID 1lvb

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